The 14 bp deletion polymorphisms in HLA‐G gene play an important role in the expression of soluble HLA‐G in plasma

XY Chen, WH Yan, A Lin, HH Xu, JG Zhang… - Tissue …, 2008 - Wiley Online Library
Soluble human leukocyte antigen‐G (sHLA‐G) functions as a multiple immunoregulator. A
14 bp insertion (+ 14 bp)/deletion (− 14 bp) polymorphism in exon 8 of the HLA‐G gene has …

Association of soluble HLA‐G plasma levels with HLA‐G alleles

V Rebmann, K Van Der Ven, M Pässler… - Tissue …, 2001 - Wiley Online Library
Soluble HLA‐G (sHLA‐G) molecules are found in the peripheral blood of healthy females
and males, in cord blood and in amniotic fluids and discussed to be a mediator in maternal …

The 14 bp deletion-insertion polymorphism in the 3′ UT region of the HLA-G gene influences HLA-G mRNA stability

P Rousseau, M Le Discorde, G Mouillot, C Marcou… - Human immunology, 2003 - Elsevier
Human leukocyte antigen (HLA)-G molecules are generated by an alternative splicing of the
primary transcript of the gene and display specialized function in regulating the immune …

The genetic structure of 3′ untranslated region of the HLA-G gene: polymorphisms and haplotypes

EC Castelli, CT Mendes-Junior, NHS Deghaide… - Genes & …, 2010 - nature.com
The HLA-G gene is predominantly expressed at the maternal–fetal interface. It has been
associated with maternal–fetal tolerance and in the inhibition of cytotoxic T lymphocyte and …

Detection of soluble HLA‐G molecules in plasma and amniotic fluid

V Rebmann, K Pfeiffer, M Pässler, S Ferrone… - Tissue …, 1999 - Wiley Online Library
Although the cDNA sequence of HLA‐G antigens is compatible with their expression as
soluble molecules (sHLA‐G), the determination of native sHLA‐G levels in body fluids has …

The expression and functional activity of membrane-bound human leukocyte antigen-G1 are influenced by the 3′-untranslated region

SG Svendsen, BM Hantash, L Zhao, C Faber… - Human immunology, 2013 - Elsevier
Human Leukocyte Antigen (HLA)-G is an immunosuppressive molecule acting on both the
innate and adaptive immune system. A 14bp insertion/deletion polymorphism (rs66554220) …

HLA-G gene polymorphism in a Japanese population

T Yamashita, T Fujii, Y Watanabe, K Tokunaga… - Immunogenetics, 1996 - Springer
Polymorphism of the HLA-G gene in a Japanese population was investigated employing
polymerase chain reaction (PCR)-single-strand conformation polymorphism (SSCP) …

Association of the HLA‐G gene +3142C>G polymorphism with systemic lupus erythematosus

CR Consiglio, TD Veit, OA Monticielo… - Tissue …, 2011 - Wiley Online Library
Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease that affects
several organs and systems. Its etiology remains unknown, although it is probably …

Association of the maternal 14‐bp insertion polymorphism in the HLA‐G gene in women with recurrent spontaneous abortions

WH Yan, A Lin, XJ Chen, MZ Dai, LH Gan… - Tissue …, 2006 - Wiley Online Library
Human leukocyte antigen (HLA)‐G has been postulated as an important immunotolerant
molecule in maintaining fetal–maternal relationship. Recent reports indicated that the 14‐bp …

Human leukocyte antigen-G polymorphism in relation to expression, function, and disease

MH Larsen, TVF Hviid - Human immunology, 2009 - Elsevier
Human leukocyte antigen-G (HLA-G) is a nonclassical class Ib molecule belonging to the
major histocompatibility complex. HLA-G appears to play a role in the suppression of …