NR5A2 gene affects the overall survival of LUAD patients by regulating the activity of CSCs through SNP pathway by OCLR algorithm and immune score

L Wu, X Chen, Q Zeng, Z Lai, Z Fan, X Ruan, X Li… - Heliyon, 2024 - cell.com
Abstract Objective Differentially expressed genes (DEGs) in lung adenocarcinoma (LUAD)
tumor stem cells were screened, and the biological characteristics of NR5A2 gene were …

Identification of Cancer Stem Cell-related Gene by Single-cell and Machine Learning Predicts Immune Status, Chemotherapy Drug, and Prognosis in Lung …

C Yang, J Zhang, J Xie, L Li, X Zhao… - Current Stem Cell …, 2024 - ingentaconnect.com
Aim: This study aimed to identify the molecular type and prognostic model of lung
adenocarcinoma (LUAD) based on cancer stem cell-related genes. Studies have shown that …

NRAS expression is associated with prognosis and tumor immune microenvironment in lung adenocarcinoma

Y Yan, Z Gao, H Han, Y Zhao, Y Zhang, X Ma… - Journal of Cancer …, 2022 - Springer
Purpose NRAS plays a pivotal role in progression of various kinds of somatic malignancies;
however, the correlation between NRAS and lung adenocarcinoma is less known. We aim to …

[HTML][HTML] The predictive prognostic values of CBFA2T3, STX3, DENR, EGLN1, FUT4, and PCDH7 in lung cancer

Y Chen, L Shen, B Chen, X Han, Y Yu… - Annals of …, 2021 - ncbi.nlm.nih.gov
Background Lung cancer is one of the most malignant tumors. However, neither the
pathogenesis of lung cancer nor the prognosis markers are completely clear. The purpose of …

Stemness genes and miR-1247-3p expression associate with clinicopathological parameters and prognosis in lung adenocarcinoma

S Limbu, KE McCloskey - Plos one, 2023 - journals.plos.org
Lung cancer makes up one-fourth of all cancer-related mortality with the highest mortality
rate among all cancers. Despite recent scientific advancements in cancer therapeutics, the 5 …

Nr5a2 promotes cancer stem cell properties and tumorigenesis in nonsmall cell lung cancer by regulating Nanog

T Ye, J Li, Z Sun, Y Liu, L Kong, S Zhou… - Cancer …, 2019 - Wiley Online Library
Lung cancer has the highest mortality rate due to late diagnosis and high incidence of
metastasis. Cancer stem cells (CSCs) are a subgroup of cancer cells with self‐renewal …

Machine learning-based immune prognostic model and ceRNA network construction for lung adenocarcinoma

X He, Y Su, P Liu, C Chen, C Chen, H Guan… - Journal of Cancer …, 2023 - Springer
Purpose Lung adenocarcinoma (LUAD) is a malignant tumor with a high lethality rate.
Immunotherapy has become a breakthrough in cancer treatment and improves patient …

Key genes involved with prognosis were identified in lung adenocarcinoma by integrated bioinformatics analysis

H Song, J Wu, W Liu, K Cai, Z Xie, Y Liu, J Huang… - Heliyon, 2023 - cell.com
Objective By screening the core genes in lung adenocarcinoma (LUAD) with bioinformatics,
our study evaluated its prognosis value and role in infiltration process of immune cells …

Immune-and stemness-related genes revealed by comprehensive analysis and validation for cancer immunity and prognosis and its nomogram in lung …

M Chen, X Wang, W Wang, X Gui, Z Li - Frontiers in Immunology, 2022 - frontiersin.org
Objective Lung adenocarcinoma (LUAD) is a familiar lung cancer with a very poor
prognosis. This study investigated the immune-and stemness-related genes to develop …

RNF115 promotes lung adenocarcinoma through Wnt/β-catenin pathway activation by mediating APC ubiquitination

XT Wu, YH Wang, XY Cai, Y Dong, Q Cui, YN Zhou… - Cancer & …, 2021 - Springer
Background Patients with lung adenocarcinoma (LUAD) have high mortality rate and poor
prognosis. The LUAD cells display increased aerobic glycolysis, which generates energy …