Abstract Background Cyclooxygenase-2 (COX-2, PTGS2) is an enzyme involved in the
synthesis of prostaglandins and thromboxanes, which are regulators of biologic processes …

AIM: Recent clinical epidemiological studies have demonstrated the preventive effect of non-
steroidal anti-inflammatory drugs (NSAIDs) against colorectal cancer. The underlying …

BACKGROUND Experimental, clinical, and epidemiological studies have implicated
mitogenic metabolites of arachidonic acid such as prostaglandin E2 (PGE2) in colorectal …

Background Increased cyclooxygenase activity promotes progression of colorectal cancer,
but the mechanisms behind COX-2 induction remain elusive. This study was therefore …

Background Cyclooxygenase-2 (COX-2) is believed to be an important enzyme in the
pathogenesis of colorectal cancer (CRC). Correlations between the expression of COX-2 …

Abstract Background/Aims: Several clinical, epidemiological, and animal studies indicate
that nonsteroidal anti-inflammatory drugs (NSAIDs) may alter the incidence of colorectal …

Background Cyclo-oxgenase 2 (COX-2) is involved in prostaglandin synthesis in central
nervous system, and it also plays a role in human carcinogenesis. Our purpose of this study …

Background: Colorectal carcinoma (CRC) is the most common neoplasm of the
gastrointestinal tract. COX-2 plays an important role in CRC development and is a key target …

The cyclooxygenase (COX) pathway is important in colorectal carcinogenesis with the
majority of cancers overexpressing COX-2; however, the role of COX-2 in the development …

A relationship between cyclooxygenase-2 (COX-2) expression and the pathogenesis of
colorectal cancer has been reported in recent studies. Moreover, it has been indicated that …