[HTML][HTML] Monitoring of blood immunosuppressant concentrations and lymphocyte activation for predicting viral infections following kidney transplantation: A pilot study
T Iwamoto, K Nishikawa - Medicine, 2022 - journals.lww.com
The current standard pharmacokinetic monitoring of immunosuppressive therapy does not
consider inter-and intra-individual differences in the biological response to multidrug …
consider inter-and intra-individual differences in the biological response to multidrug …
Usefulness of monitoring cell-mediated immunity for predicting Post–kidney transplantation viral infection
K Nishikawa, S Mizuno, S Masui, H Kanda… - Transplantation …, 2014 - Elsevier
Background Monitoring cell-mediated immunity (CMI) can be used to estimate the risk of
viral infections in kidney transplant recipients. The Immuknow (IMK) assay measures CD4+ …
viral infections in kidney transplant recipients. The Immuknow (IMK) assay measures CD4+ …
Immune function assay (immunknow) drop over first 6 months after renal transplant: a predictor of opportunistic viral infections?
M Quaglia, T Cena, R Fenoglio, C Musetti… - Transplantation …, 2014 - Elsevier
Abstract Background The Immuknow assay (IKA; Cylex) is a T-cell immune function assay
that evaluates immunoreactivity in immunocompromised patients. The aim of this study was …
that evaluates immunoreactivity in immunocompromised patients. The aim of this study was …
[HTML][HTML] A Polyclonal Immune Function Assay Allows Dose-Dependent Characterization of Immunosuppressive Drug Effects but Has Limited Clinical Utility for …
S Marx, C Adam, J Mihm, M Weyrich, U Sester… - Frontiers in …, 2020 - frontiersin.org
Dosage of immunosuppressive drugs after transplantation critically determines rejection and
infection episodes. In this study, a global immune function assay was characterized among …
infection episodes. In this study, a global immune function assay was characterized among …
Quantification of immunosuppression by flow cytometry in stable renal transplant recipients
M Stalder, T Bîrsan, B Holm, M Haririfar… - Therapeutic drug …, 2003 - journals.lww.com
The current standard of monitoring transplant patients by drug levels is not optimal because
it does not take into account the different and individual effects of immunosuppressive drugs …
it does not take into account the different and individual effects of immunosuppressive drugs …
Cell mediated immunity (CMI) and post transplant viral infections—Role of a functional immune assay to titrate immunosuppression
A Gautam, SA Fischer, AF Yango, RY Gohh… - International …, 2006 - Elsevier
Cell mediated immunity (CMI) was assessed by the ImmuKnow assay in 12 patients after
kidney transplantation, who presented with viral infection. Treatment included lowering of …
kidney transplantation, who presented with viral infection. Treatment included lowering of …
Sensitivity of whole-blood T lymphocytes in individual patients to tacrolimus (FK 506): impact of interleukin-2 mRNA expression as surrogate measure of …
C Hartel, N Schumacher, L Fricke, B Ebel… - Clinical …, 2004 - academic.oup.com
Background: To optimize immunosuppressive treatment in individual transplant patients,
functional measurements of the effects of tacrolimus (FK 506) are of clinical importance …
functional measurements of the effects of tacrolimus (FK 506) are of clinical importance …
Immune responsiveness in stable kidney transplantation patients: Complete inhibition of T‐cell proliferation but residual T‐cell activity during maintenance …
AE in't Veld, BC Eveleens Maarse… - Clinical and …, 2024 - Wiley Online Library
The recommended immunosuppressive treatment after kidney transplantation consists of
tacrolimus, mycophenolate mofetil, and low‐dose corticosteroids. Drug concentrations are …
tacrolimus, mycophenolate mofetil, and low‐dose corticosteroids. Drug concentrations are …
Kinetics of peripheral blood lymphocyte subpopulations predicts the occurrence of opportunistic infection after kidney transplantation
M Fernández‐Ruiz, F López‐Medrano… - Transplant …, 2014 - Wiley Online Library
Serial monitoring of peripheral blood lymphocyte subpopulations (PBLS s) counts might be
useful in predicting post‐transplant opportunistic infection (OI) after kidney transplantation …
useful in predicting post‐transplant opportunistic infection (OI) after kidney transplantation …
[HTML][HTML] Pretransplant levels of C-reactive protein, soluble TNF receptor-1, and CD38+ HLADR+ CD8 T cells predict risk of allograft rejection in HIV+ kidney transplant …
Introduction HIV-positive (HIV+) kidney transplant recipients exhibit a 2-to 3-fold increased
risk of allograft rejection. Dysregulated immune activation in HIV infection persists despite …
risk of allograft rejection. Dysregulated immune activation in HIV infection persists despite …