Mycobacterium paratuberculosis has been suggested to be involved in the pathogenesis of
Crohn's disease (CD). The importance of microorganisms in CD is supported by the …

Infection with Mycobacterium tuberculosis is one of the leading causes of death worldwide.
Recognition of M. tuberculosis by pattern recognition receptors is crucial for activation of …

Macrophages respond to several subcellular products of Mycobacterium tuberculosis (Mtb)
through TLR2 or TLR4. However, primary mouse macrophages respond to viable, virulent …

Recognition of Mycobacterium tuberculosis by the innate immune system is essential in the
development of an adaptive immune response. Mycobacterial cell wall components activate …

Mycobacterium tuberculosis possesses agonists for several Toll-like receptors (TLRs), yet
mice with single TLR deletions are resistant to acute tuberculosis. MyD88−/− mice were …

Endotoxin from Gram-negative bacteria bound to CD14 signals through Toll-like receptor
(TLR) 4, while components of Gram-positive bacteria, fungi, and Mycobacterium tuberculosis …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a major health problem,
with 10 million new cases diagnosed each year. Innate immunity plays an important role in …

Innate resistance against Mycobacterium tuberculosis is thought to depend critically on
engagement of pattern recognition receptors on macrophages. However, the relative …

The role of Toll‐like receptors (TLR) and MyD88 for immune responses to Mycobacterium
tuberculosis (Mtb) infection remains controversial. To address the impact of TLR‐mediated …

An efficient immune response against the intracellular pathogen Mycobacterium
tuberculosis is critically dependent on rapid detection of the invader by the innate immune …