hnRNPK-derived cell-penetrating peptide inhibits cancer cell survival

PK Puvvula, S Buczkowski, AM Moon - Molecular Therapy-Oncolytics, 2021 - cell.com
hnRNPK is a multifunctional protein that plays an important role in cancer cell proliferation
and metastasis via its RNA-and DNA-binding properties. Previously we showed that cell …

NKp44-derived peptide binds proliferating cell nuclear antigen and mediates tumor cell death

A Shemesh, K Kundu, R Peleg, R Yossef… - Frontiers in …, 2018 - frontiersin.org
Proliferating cell nuclear antigen (PCNA) is considered as a hub protein and is a key
regulator of DNA replication, repair, cell cycle control, and apoptosis. PCNA is …

[HTML][HTML] Necrosis-inducing peptide has the beneficial effect on killing tumor cells through neuropilin (NRP-1) targeting

JY Kim, JH Han, G Park, YW Seo, CW Yun, BC Lee… - Oncotarget, 2016 - ncbi.nlm.nih.gov
The therapeutic efficacy of most anti-cancer drugs depends on their apoptosis-inducing
abilities. Previously, we showed that a peptide containing the mitochondrial targeting …

Emerging roles of hnRNPA1 in modulating malignant transformation

R Roy, Y Huang, MJ Seckl… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are RNA‐binding proteins associated
with complex and diverse biological processes such as processing of heterogeneous …

HnRNP-F regulates EMT in bladder cancer by mediating the stabilization of Snail1 mRNA by binding to its 3′ UTR

F Li, H Zhao, M Su, W Xie, Y Fang, Y Du, Z Yu, L Hou… - …, 2019 - thelancet.com
Background Heterogeneous nuclear ribonucleoprotein F (hnRNP-F) has been implicated in
multiple cancers, suggesting its role in tumourigenesis, but the potential oncogenic role and …

Improved anticancer efficacy of doxorubicin mediated by human-derived cell-penetrating peptide dNP2

Y Xiang, W Shan, Y Huang - International journal of pharmaceutics, 2018 - Elsevier
Although cell penetrating peptides (CPPs) have been extensively studied as an approach to
deliver anti-cancer drugs into the tumor cells for the last 30 years, no FDA-approved CPP …

[HTML][HTML] HnRNP-L promotes prostate cancer progression by enhancing cell cycling and inhibiting apoptosis

X Zhou, Q Li, J He, L Zhong, F Shu, R Xing, D Lv… - …, 2016 - pmc.ncbi.nlm.nih.gov
Expression of the RNA-binding protein HnRNP-L was previously shown to associate with
tumorigenesis in liver and lung cancer. In this study, we examined the role of HnRNP-L in …

A Human GSDMD Protein-Derived Cell-Penetrating Peptide Enhances the Antitumor Effects of the Proapoptotic Peptide KLA

X Kong, N Li, RX Ning, YK Liu, JH Wu, CY Liu… - Journal of Drug Delivery …, 2024 - Elsevier
Cell-penetrating peptides (CPPs) possess significant potential for the transportation of cell-
impermeable biological molecules into tumor cells. However, the nonhuman origins of CPPs …

Regulation and related mechanism of GSN mRNA level by hnRNPK in lung adenocarcinoma cells

X Liu, J Ma, J Feng, Y Feng, Y Zhang, L Liu - Biological Chemistry, 2019 - degruyter.com
Gelsolin (GSN) is an actin filament-capping protein that plays a key role in cell migration.
Here we show that heterogeneous nuclear ribonucleoprotein K (hnRNPK) regulates GSN …

Identification of an mRNA isoform switch for HNRNPA1 in breast cancers

M Erdem, İ Ozgul, DN Dioken, I Gurcuoglu… - Scientific Reports, 2021 - nature.com
Roles of HNRNPA1 are beginning to emerge in cancers; however, mechanisms causing
deregulation of HNRNPA1 function remain elusive. Here, we describe an isoform switch …