5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs

X Chen, A Li, BF Sun, Y Yang, YN Han, X Yuan… - Nature cell …, 2019 - nature.com
Abstract Although 5-methylcytosine (m5C) is a widespread modification in RNAs, its
regulation and biological role in pathological conditions (such as cancer) remain unknown …

[HTML][HTML] NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization

J Su, G Wu, Y Ye, J Zhang, L Zeng, X Huang, Y Zheng… - Oncogene, 2021 - nature.com
Methylcytosine (m5C) is a posttranscriptional RNA modification participating in many critical
bioprocesses, but its functions in human cancer remain unclear. Here, by detecting the …

[HTML][HTML] m5C-dependent cross-regulation between nuclear reader ALYREF and writer NSUN2 promotes urothelial bladder cancer malignancy through facilitating …

N Wang, R Chen, M Deng, W Wei, Z Zhou, K Ning… - Cell Death & …, 2023 - nature.com
The significance of 5-methylcytosine (m5C) methylation in human malignancies has become
an increasing focus of investigation. Here, we show that m5C regulators including writers …

DMDRMR-Mediated Regulation of m6A-Modified CDK4 by m6A Reader IGF2BP3 Drives ccRCC Progression

Y Gu, S Niu, Y Wang, L Duan, Y Pan, Z Tong, X Zhang… - Cancer research, 2021 - AACR
Abstract Aberrant N 6-methyladenosine (m6A) modification has emerged as a driver of
tumor initiation and progression, yet how long noncoding RNAs (lncRNA) are involved in the …

[HTML][HTML] METTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets

KW Hsu, JCY Lai, JS Chang, PH Peng, CH Huang… - Genome biology, 2022 - Springer
Abstract Background DNA N6-methyldeoxyadenosine (6mA) is rarely present in mammalian
cells and its nuclear role remains elusive. Results Here we show that hypoxia induces …

[HTML][HTML] TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer

Z Su, I Monshaugen, B Wilson, F Wang… - Nature …, 2022 - nature.com
RNA modifications are important regulatory elements of RNA functions. However, most
genome-wide mapping of RNA modifications has focused on messenger RNAs and transfer …

The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network

M Cheng, L Sheng, Q Gao, Q Xiong, H Zhang, M Wu… - Oncogene, 2019 - nature.com
Abstract N 6-methyladenosine (m6A) is the most abundant modification in eukaryotic
messenger RNAs (mRNAs), and plays important roles in many bioprocesses. However, its …

[HTML][HTML] Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression

W Song, K Yang, J Luo, Z Gao, Y Gao - Aging (albany NY), 2021 - ncbi.nlm.nih.gov
N6-methyladenosine refers to a methylation of adenosine base at the 6 th nitrogen position,
which is the dominant methylation modification in both message and non-coding RNAs …

Super-enhancer RNA m6A promotes local chromatin accessibility and oncogene transcription in pancreatic ductal adenocarcinoma

R Li, H Zhao, X Huang, J Zhang, R Bai, L Zhuang… - Nature Genetics, 2023 - nature.com
The biological functions of noncoding RNA N 6-methyladenosine (m6A) modification remain
poorly understood. In the present study, we depict the landscape of super-enhancer RNA …

METTL3/YTHDF2 m6A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer

H Xie, J Li, Y Ying, H Yan, K Jin, X Ma… - Journal of cellular …, 2020 - Wiley Online Library
Abstract N6‐Methyladenosine (m6A) modification, the most prevalent modification of
eukaryotic messenger RNA (mRNA), is involved in the progression of various tumours …