Design, synthesis and biological evaluation of a series of dianilinopyrimidines as EGFR inhibitors
L Yan, Q Wang, L Liu, Y Le - Journal of Enzyme Inhibition and …, 2022 - Taylor & Francis
This paper described our efforts to develop dianilinopyrimidines as novel EGFR inhibitors.
All the target compounds were tested for inhibitory effects against wild type EGFR (EGFRwt) …
All the target compounds were tested for inhibitory effects against wild type EGFR (EGFRwt) …
Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors
Y Zuo, R Li, Y Zhang, G Bao, Y Le… - Journal of Enzyme …, 2022 - Taylor & Francis
A new series of 5-trifluoromethylpyrimidine derivatives were designed and synthesised as
EGFR inhibitors. Three tumour cells A549, MCF-7, PC-3 and EGFR kinase were employed …
EGFR inhibitors. Three tumour cells A549, MCF-7, PC-3 and EGFR kinase were employed …
Facile and efficient synthesis and biological evaluation of 4-anilinoquinazoline derivatives as EGFR inhibitors
Z Wang, X Wu, L Wang, J Zhang, J Liu, Z Song… - Bioorganic & Medicinal …, 2016 - Elsevier
Abstract Series of 4-anilinoquinazoline derivatives were conveniently and efficiently
synthesized and their antitumor activities were evaluated by MTT assay in three human …
synthesized and their antitumor activities were evaluated by MTT assay in three human …
Design, synthesis and biological evaluation of novel 4-anlinoquinazoline derivatives as EGFR inhibitors with the potential to inhibit the gefitinib-resistant nonsmall cell …
C Wang, S Xu, L Peng, B Zhang, H Zhang… - Journal of Enzyme …, 2019 - Taylor & Francis
A series of quinazoline derivatives with benzylidene hydrazine carboxamide were designed
and synthesised as EGFR inhibitors. Most compounds exhibited exceptional anti …
and synthesised as EGFR inhibitors. Most compounds exhibited exceptional anti …
Design and synthesis of 4, 6-substituted-(diaphenylamino) quinazolines as potent EGFR inhibitors with antitumor activity
HQ Li, DD Li, X Lu, YY Xu, HL Zhu - Bioorganic & medicinal chemistry, 2012 - Elsevier
A type of novel 4, 6-substituted-(diaphenylamino) quinazolines, which designed based on
the 4-(phenylamino) quinazoline moiety, have been discovered as potential EGFR …
the 4-(phenylamino) quinazoline moiety, have been discovered as potential EGFR …
Design and Synthesis of some new 2, 4, 6-trisubstituted quinazoline EGFR inhibitors as targeted anticancer agents
HA Allam, EE Aly, AK Farouk, AM El Kerdawy… - Bioorganic …, 2020 - Elsevier
The present study describes the synthesis of 6-bromo-2-(pyridin-3-yl)-4-substituted
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …
6‐Aryl and Heterocycle Quinazoline Derivatives as Potent EGFR Inhibitors with Improved Activity toward Gefitinib‐Sensitive and‐Resistant Tumor Cell Lines
MM Hamed, DA Abou El Ella, AB Keeton… - …, 2013 - Wiley Online Library
A group of novel anilinoquinazoline derivatives with variable aryl and heterocyclic
substituents at position 6 were synthesized and tested for their EGFR‐inhibitory activity. Aryl …
substituents at position 6 were synthesized and tested for their EGFR‐inhibitory activity. Aryl …
Novel quinazoline derivatives bearing various 4‐aniline moieties as potent EGFR inhibitors with enhanced activity against NSCLC cell lines
C Wang, Y Sun, X Zhu, B Wu, Q Wang… - Chemical Biology & …, 2016 - Wiley Online Library
A class of novel quinazoline derivatives bearing various C‐4 aniline moieties was
synthesized and biologically evaluated as potent epidermal growth factor receptor (EGFR) …
synthesized and biologically evaluated as potent epidermal growth factor receptor (EGFR) …
Novel 5-bromoindole-2-carboxylic acid derivatives as EGFR inhibitors: synthesis, docking study, and structure activity relationship
OM Hassan, A Kubba… - Anti-Cancer Agents in …, 2023 - ingentaconnect.com
Background: The indole backbone is encountered in a class of N-heterocyclic compounds
with physiological and pharmacological effects such as anti-cancer, anti-diabetic, and anti …
with physiological and pharmacological effects such as anti-cancer, anti-diabetic, and anti …
New pyrimidine-5-carbonitrile derivatives as EGFR inhibitors with anticancer and apoptotic activities: design, molecular modeling and synthesis
IA Osman, RR Ayyad, HA Mahdy - New Journal of Chemistry, 2022 - pubs.rsc.org
In connection with our efforts in the development of new anticancer agents, herein we report
the design and synthesis of new small pyrimidine-5-carbonitrile based derivatives. The …
the design and synthesis of new small pyrimidine-5-carbonitrile based derivatives. The …