Recent studies across multiple tumour types are starting to reveal a recurrent regulatory
architecture in which genomic alterations cluster upstream of functional master regulator …

Despite considerable efforts, the mechanisms linking genomic alterations to the
transcriptional identity of cancer cells remain elusive. Integrative genomic analysis, using a …

The p53 pathway is perturbed in the majority of human cancers. Although this most
frequently occurs through the direct mutation or deletion of p53 itself, there are a number of …

Genomic and proteomic profiling of human tumor samples and tumor-derived cell lines are
essential for the realization of personalized therapy in oncology. Identification of the …

Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …

More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …

The tumor suppressor p53 is a master sensor of stress that controls many biological
functions, including implantation, cell-fate decisions, metabolism, and aging. In response to …

p53 has been studied intensively as a major tumour suppressor that detects oncogenic
events in cancer cells and eliminates them through senescence (a permanent non …

Deregulation of the cell cycle underlies the aberrant cell proliferation that characterizes
cancer and loss of cell cycle checkpoint control promotes genetic instability. During the past …