Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment

DL Eaton, RB Daroff, H Autrup, J Bridges… - Critical reviews in …, 2008 - Taylor & Francis
This review examines the large body of toxicological and epidemiological information on
human exposures to chlorpyrifos, with an emphasis on the controversial potential for …

Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period?

D Qiao, FJ Seidler, S Padilla… - Environmental health …, 2002 - ehp.niehs.nih.gov
Previously, we found that exposure of neonatal rats to chlorpyrifos (CPF) produced brain cell
damage and loss, with resultant abnormalities of synaptic development. We used the same …

Fetal chlorpyrifos exposure: adverse effects on brain cell development and cholinergic biomarkers emerge postnatally and continue into adolescence and adulthood.

D Qiao, FJ Seidler, CA Tate, MM Cousins… - Environmental health …, 2003 - ehp.niehs.nih.gov
Fetal and childhood exposures to widely used organophosphate pesticides, especially
chlorpyrifos (CPF), have raised concerns about developmental neurotoxicity. Previously …

[HTML][HTML] Chlorpyrifos and neurodevelopmental effects: a literature review and expert elicitation on research and policy

M Saunders, BL Magnanti, S Correia Carreira… - Environmental …, 2012 - Springer
Background Organophosphate pesticides are widely used on food crops grown in the EU.
While they have been banned from indoor use in the US for a decade due to adverse health …

Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children

VA Rauh, R Garfinkel, FP Perera, HF Andrews… - …, 2006 - publications.aap.org
OBJECTIVE. The purpose of this study was to investigate the impact of prenatal exposure to
chlorpyrifos on 3-year neurodevelopment and behavior in a sample of inner-city minority …

Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathways

K Dam, SJ Garcia, FJ Seidler, TA Slotkin - Developmental Brain Research, 1999 - Elsevier
After routine home application of chlorpyrifos (CPF), infant and child exposures can exceed
acceptable levels. We treated neonatal rats daily on postnatal days (PN) 1–4 (1 mg/kg) or …

Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations

ED Levin, N Addy, A Baruah, A Elias… - Neurotoxicology and …, 2002 - Elsevier
Use of chlorpyrifos (CPF) has been curtailed due to its developmental neurotoxicity. In rats,
postnatal CPF administration produces lasting changes in cognitive performance, but less …

Chlorpyrifos exposure during neurulation: cholinergic synaptic dysfunction and cellular alterations in brain regions at adolescence and adulthood

D Qiao, FJ Seidler, Y Abreu-Villaça, CA Tate… - Developmental brain …, 2004 - Elsevier
The developmental neurotoxicity of chlorpyrifos (CPF) involves multiple mechanisms, thus
rendering the immature brain susceptible to adverse effects over a wide window of …

Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation

TL Crumpton, FJ Seidler, TA Slotkin - Brain research, 2000 - Elsevier
Chlorpyrifos is a widely used organophosphate insecticide that is a suspected
developmental neurotoxin. Although chlorpyrifos exerts some effects through cholinesterase …

Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposure

JE Aldridge, A Meyer, FJ Seidler… - Environmental health …, 2005 - ehp.niehs.nih.gov
Exposure to chlorpyrifos (CPF) alters neuronal development of serotonin (5HT) and
dopamine systems, and we recently found long-term alterations in behaviors related to 5HT …