Recent advances in clinical practice: management of inflammatory bowel disease during the COVID-19 pandemic

S Lin, LHS Lau, N Chanchlani, NA Kennedy, SC Ng - Gut, 2022 - gut.bmj.com
The COVID-19 pandemic has raised considerable concerns that patients with inflammatory
bowel disease (IBD), particularly those treated with immunosuppressive therapies, may …

Reduced serological response to COVID-19 vaccines in patients with IBD is further diminished by TNF inhibitor therapy; early results of the VARIATION study …

J Doherty, NO Morain, R Stack, P Girod… - Journal of Crohn's …, 2022 - academic.oup.com
Abstract Background and Aims Evidence suggests patients with inflammatory bowel disease
[IBD] receiving TNF antagonists have attenuated response to vaccination against COVID-19 …

[HTML][HTML] COVID-19 vaccine-induced antibody responses in immunosuppressed patients with inflammatory bowel disease (VIP): a multicentre, prospective, case …

JL Alexander, NA Kennedy, H Ibraheim… - The lancet …, 2022 - thelancet.com
Background The effects that therapies for inflammatory bowel disease (IBD) have on
immune responses to SARS-CoV-2 vaccination are not yet fully known. Therefore, we …

Factors affecting initial humoral immune response to SARS-CoV-2 vaccines among patients with inflammatory bowel diseases

MD Kappelman, KN Weaver, X Zhang… - Official journal of the …, 2022 - journals.lww.com
METHODS: In this prospective cohort of SARS-CoV-2 immunized patients with IBD, we
evaluated associations between participant age, sex, vaccine type, medication use, and the …

Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab

NA Kennedy, JR Goodhand, C Bewshea, R Nice… - Gut, 2021 - gut.bmj.com
Objective Antitumour necrosis factor (anti-TNF) drugs impair protective immunity following
pneumococcal, influenza and viral hepatitis vaccination and increase the risk of serious …

Therapies for inflammatory bowel disease do not pose additional risks for adverse outcomes of SARS‐CoV‐2 infection: an IG‐IBD study

C Bezzio, A Armuzzi, F Furfaro… - Alimentary …, 2021 - Wiley Online Library
Background Older age and comorbidities are the main risk factors for adverse COVID‐19
outcomes in patients with inflammatory bowel disease (IBD). The impact of IBD medications …

COVID-19 vaccine is effective in inflammatory bowel disease patients and is not associated with disease exacerbation

R Lev-Tzion, G Focht, R Lujan, A Mendelovici… - Clinical …, 2022 - Elsevier
Background & Aims Studies have shown decreased response to coronavirus disease 2019
(COVID-19) vaccinations in some populations. In addition, it is possible that vaccine …

Anti-SARS-CoV-2 vaccination and antibody response in patients with inflammatory bowel disease on immune-modifying therapy: prospective single-tertiary study

K Cerna, D Duricova, M Lukas… - Inflammatory Bowel …, 2022 - academic.oup.com
Background Patients with inflammatory bowel disease (IBD) on immune-modifying treatment
could be at an increased risk for severe coronavirus disease 2019 (COVID-19); thus, data on …

Crohn's and Colitis Canada's 2021 Impact of COVID-19 and Inflammatory Bowel Disease in Canada: COVID-19 Vaccines—Biology, Current Evidence and …

SK Murthy, ME Kuenzig, JW Windsor… - Journal of the …, 2021 - academic.oup.com
The COVID-19 pandemic has ushered a globally focused vaccine development program
that produced multiple successful vaccines within a year. Four SARS-CoV-2 vaccines have …

Impact of inflammatory bowel disease therapies on durability of humoral response to SARS-CoV-2 vaccination

P Charilaou, C Tricarico, R Battat, EJ Scherl… - Clinical …, 2022 - cghjournal.org
Immunization against the spike protein of SARS-CoV-2 reduces transmission 1, 2 and
severe outcomes. However, little is known regarding the impact of immune-mediated …