The pathogenesis of sepsis-associated acute kidney injury is complex and likely involves
perfusion alterations, a dysregulated inflammatory response, and bioenergetic …

The renal microcirculation plays a major role in the delivery of blood and oxygen to the
kidney. In sepsis, alterations in renal microvascular perfusion, in conjunction with increased …

Renal tissue hypoxia has been implicated as a critical mediatory factor in multiple forms of
acute kidney injury (AKI), including in sepsis. In sepsis, whole-kidney measures of …

Sepsis is considered a major public health problem. Despite mortality being associated
consistently with organ compromise, the mechanisms by which sepsis causes multiple …

Traditionally, renal ischemia has been regarded as central to the pathogenesis of sepsis-
associated acute kidney injury (SA-AKI). Accordingly, hemodynamic management of SA-AKI …

Sepsis is the commonest cause of acute kidney injury in critically ill patients. Its
pathophysiology is complex and not well understood. Until recently, it was believed that …

Despite identification of several cellular mechanisms being thought to underlie the
development of septic acute kidney injury (AKI), the pathophysiology of the occurrence of …

Given that the leading clinical conditions associated with acute kidney injury (AKI), namely,
sepsis, major surgery, heart failure, and hypovolemia, are all associated with shock, it is …

Sepsis is a complex clinical syndrome characterized by a systemic inflammatory response to
an infective insult. This process often leads to widespread tissue injury and multiple organ …

Sepsis-induced acute kidney injury (AKI) is the most common form of AKI observed in
critically ill patients. AKI mortality in septic critically ill patients remains high despite our …