Proteases play a crucial role in the progression and metastasis of ovarian cancer.
Pericellular protein degradation and fragmentation along with remodeling of the …

Ovarian cancer is the leading cause of death from gynecologic malignancies. Reasons for
the high mortality rate associated with ovarian cancer include a late diagnosis at which time …

Epithelial ovarian cancer is the leading cause of death from gynecologic malignancy among
North American women. The vast majority of women are diagnosed after the cancer has …

Ovarian cancer is one of the most malignant genital cancers, with a high mortality rate. Many
researchers have suggested that matrix metalloproteinases (MMPs) have remarkably high …

The role for matrix metalloproteinases (MMPs) in tumor cells invasion and metastasis is well
established, and expression of MMPs is recognized as an indication of tumor cell …

Substantial evidence indicates that proteolytic degradation of the extracellular matrix is
necessary for invasion and metastasis by cancer cells. Our previous work has demonstrated …

Purpose: Matrix metalloproteinases (MMP) are proteolytic enzymes implicated in cancer
progression and metastasis. We sought to determine the role of epithelial (tumor cell …

Abstract Background Matrix metalloproteinases (MMPs) are involved in the degradation of
protein components of the extracellular matrix and thus play an important role in tumor …

The extracellular matrix (ECM) provides a physical framework for the cells and functions as a
gel medium. Remodeling of the ECM is crucial during physiological cell migration …

Proteases are crucial for development, tissue remodeling, and tumorigenesis. Matrix
metalloproteinases (MMPs) family, in particular, consists of more than 20 members with …