Inactivated cowpea mosaic virus for in situ vaccination: differential efficacy of formalin vs UV-inactivated formulations
E Jung, C Mao, M Bhatia, EC Koellhoffer… - Molecular …, 2022 - ACS Publications
Cowpea mosaic virus (CPMV) has been developed as a promising nanoplatform technology
for cancer immunotherapy; when applied as in situ vaccine, CPMV exhibits potent, systemic …
for cancer immunotherapy; when applied as in situ vaccine, CPMV exhibits potent, systemic …
In situ vaccine application of inactivated CPMV nanoparticles for cancer immunotherapy
PL Chariou, V Beiss, Y Ma, NF Steinmetz - Materials advances, 2021 - pubs.rsc.org
Cowpea mosaic virus (CPMV) is currently in the development pipeline for multiple
biomedical applications, including cancer immunotherapy. In particular the application of …
biomedical applications, including cancer immunotherapy. In particular the application of …
In vivo fate of cowpea mosaic virus in situ vaccine: biodistribution and clearance
JF Affonso de Oliveira, SK Chan, AO Omole… - ACS …, 2022 - ACS Publications
Cowpea mosaic virus (CPMV) is a nucleoprotein nanoparticle that functions as a highly
potent immunomodulator when administered intratumorally and is used as an in situ …
potent immunomodulator when administered intratumorally and is used as an in situ …
The Potency of Cowpea Mosaic Virus Particles for Cancer In Situ Vaccination Is Unaffected by the Specific Encapsidated Viral RNA
E Jung, YH Chung, C Mao, SN Fiering… - Molecular …, 2023 - ACS Publications
Plant virus nanoparticles can be used as drug carriers, imaging reagents, vaccine carriers,
and immune adjuvants in the formulation of intratumoral in situ cancer vaccines. One …
and immune adjuvants in the formulation of intratumoral in situ cancer vaccines. One …
Cowpea mosaic virus nanoparticles and empty virus-like particles show distinct but overlapping immunostimulatory properties
C Wang, V Beiss, NF Steinmetz - Journal of virology, 2019 - Am Soc Microbiol
Cowpea mosaic virus (CPMV) is a plant virus that has been developed for multiple
biomedical and nanotechnology applications, including immunotherapy. Two key platforms …
biomedical and nanotechnology applications, including immunotherapy. Two key platforms …
Cowpea mosaic virus intratumoral immunotherapy maintains stability and efficacy after long‐term storage
Cowpea mosaic virus (CPMV) has demonstrated superior immune stimulation and efficacy
as an intratumoral immunotherapy, providing a strong argument for its clinical translation …
as an intratumoral immunotherapy, providing a strong argument for its clinical translation …
Freeze-drying to produce efficacious CPMV virus-like particles
In situ cancer vaccination that uses immune stimulating agents is revolutionizing the way
that cancer is treated. In this realm, viruses and noninfectious virus-like particles have …
that cancer is treated. In this realm, viruses and noninfectious virus-like particles have …
In situ vaccination with cowpea vs tobacco mosaic virus against melanoma
AA Murray, C Wang, S Fiering… - Molecular …, 2018 - ACS Publications
Cancer immunotherapy approaches have emerged as novel treatment regimens against
cancer. A particularly interesting avenue is the concept of in situ vaccination, where …
cancer. A particularly interesting avenue is the concept of in situ vaccination, where …
Inactivated cowpea mosaic virus in combination with OX40 agonist primes potent antitumor immunity in a bilateral melanoma mouse model
EC Koellhoffer, C Mao, V Beiss, L Wang… - Molecular …, 2022 - ACS Publications
Viral immunotherapies are being recognized in cancer treatment, with several currently
approved or undergoing clinical testing. While contemporary approaches have focused on …
approved or undergoing clinical testing. While contemporary approaches have focused on …
Cowpea mosaic virus outperforms other members of the Secoviridae as in situ vaccine for cancer immunotherapy
V Beiss, C Mao, SN Fiering… - Molecular …, 2022 - ACS Publications
In situ vaccination for cancer immunotherapy uses intratumoral administration of small
molecules, proteins, nanoparticles, or viruses that activate pathogen recognition receptors …
molecules, proteins, nanoparticles, or viruses that activate pathogen recognition receptors …