Inactivated cowpea mosaic virus for in situ vaccination: differential efficacy of formalin vs UV-inactivated formulations

E Jung, C Mao, M Bhatia, EC Koellhoffer… - Molecular …, 2022 - ACS Publications
Cowpea mosaic virus (CPMV) has been developed as a promising nanoplatform technology
for cancer immunotherapy; when applied as in situ vaccine, CPMV exhibits potent, systemic …

In situ vaccine application of inactivated CPMV nanoparticles for cancer immunotherapy

PL Chariou, V Beiss, Y Ma, NF Steinmetz - Materials advances, 2021 - pubs.rsc.org
Cowpea mosaic virus (CPMV) is currently in the development pipeline for multiple
biomedical applications, including cancer immunotherapy. In particular the application of …

In vivo fate of cowpea mosaic virus in situ vaccine: biodistribution and clearance

JF Affonso de Oliveira, SK Chan, AO Omole… - ACS …, 2022 - ACS Publications
Cowpea mosaic virus (CPMV) is a nucleoprotein nanoparticle that functions as a highly
potent immunomodulator when administered intratumorally and is used as an in situ …

The Potency of Cowpea Mosaic Virus Particles for Cancer In Situ Vaccination Is Unaffected by the Specific Encapsidated Viral RNA

E Jung, YH Chung, C Mao, SN Fiering… - Molecular …, 2023 - ACS Publications
Plant virus nanoparticles can be used as drug carriers, imaging reagents, vaccine carriers,
and immune adjuvants in the formulation of intratumoral in situ cancer vaccines. One …

Cowpea mosaic virus nanoparticles and empty virus-like particles show distinct but overlapping immunostimulatory properties

C Wang, V Beiss, NF Steinmetz - Journal of virology, 2019 - Am Soc Microbiol
Cowpea mosaic virus (CPMV) is a plant virus that has been developed for multiple
biomedical and nanotechnology applications, including immunotherapy. Two key platforms …

Cowpea mosaic virus intratumoral immunotherapy maintains stability and efficacy after long‐term storage

A Simms, Z Zhao, E Cedrone… - Bioengineering & …, 2024 - Wiley Online Library
Cowpea mosaic virus (CPMV) has demonstrated superior immune stimulation and efficacy
as an intratumoral immunotherapy, providing a strong argument for its clinical translation …

Freeze-drying to produce efficacious CPMV virus-like particles

Y Zheng, PW Lee, C Wang, LD Thomas, PL Stewart… - Nano …, 2019 - ACS Publications
In situ cancer vaccination that uses immune stimulating agents is revolutionizing the way
that cancer is treated. In this realm, viruses and noninfectious virus-like particles have …

In situ vaccination with cowpea vs tobacco mosaic virus against melanoma

AA Murray, C Wang, S Fiering… - Molecular …, 2018 - ACS Publications
Cancer immunotherapy approaches have emerged as novel treatment regimens against
cancer. A particularly interesting avenue is the concept of in situ vaccination, where …

Inactivated cowpea mosaic virus in combination with OX40 agonist primes potent antitumor immunity in a bilateral melanoma mouse model

EC Koellhoffer, C Mao, V Beiss, L Wang… - Molecular …, 2022 - ACS Publications
Viral immunotherapies are being recognized in cancer treatment, with several currently
approved or undergoing clinical testing. While contemporary approaches have focused on …

Cowpea mosaic virus outperforms other members of the Secoviridae as in situ vaccine for cancer immunotherapy

V Beiss, C Mao, SN Fiering… - Molecular …, 2022 - ACS Publications
In situ vaccination for cancer immunotherapy uses intratumoral administration of small
molecules, proteins, nanoparticles, or viruses that activate pathogen recognition receptors …