Delivery of macromolecules using arginine-rich cell-penetrating peptides: ways to overcome endosomal entrapment

A El-Sayed, S Futaki, H Harashima - The AAPS journal, 2009 - Springer
Arginine-rich cell-penetrating peptides (AR-CPPs) are very promising tools for the delivery of
therapeutic macromolecules such as peptides, proteins, and nucleic acids. These peptides …

Improving the endosomal escape of cell-penetrating peptides and their cargos: strategies and challenges

A Erazo-Oliveras, N Muthukrishnan, R Baker… - Pharmaceuticals, 2012 - mdpi.com
Cell penetrating peptides (CPPs) can deliver cell-impermeable therapeutic cargos into cells.
In particular, CPP-cargo conjugates tend to accumulate inside cells by endocytosis …

Arginine-rich cell penetrating peptides: from endosomal uptake to nuclear delivery

K Melikov, LV Chernomordik - Cellular and Molecular Life Sciences CMLS, 2005 - Springer
Delivery of macromolecules into living cells by arginine-rich cell penetrating peptides (AR-
CPPs) is an important new avenue for the development of novel therapeutic strategies …

Breaking in and busting out: Cell-penetrating peptides and the endosomal escape problem

JC LeCher, SJ Nowak, JL McMurry - Biomolecular concepts, 2017 - degruyter.com
Cell-penetrating peptides (CPPs) have long held great promise for the manipulation of living
cells for therapeutic and research purposes. They allow a wide array of biomolecules from …

Arginine-rich peptides: methods of translocation through biological membranes.

S Futaki, H Hirose, I Nakase - Current pharmaceutical design, 2013 - europepmc.org
Intracellular delivery using cell-penetrating peptides (CPPs) has received considerable
attention as a promising method for introducing exogenous molecules into cells. The …

Oligoarginine vectors for intracellular delivery: Design and cellular‐uptake mechanisms

S Futaki - Peptide Science: Original Research on Biomolecules, 2006 - Wiley Online Library
Intracellular delivery using membrane‐permeable peptide vectors is a recently developed
methodology that has been employed successfully to transport various bioactive molecules …

Cell-penetrating peptides for drug delivery across membrane barriers

C Foged, HM Nielsen - Expert opinion on drug delivery, 2008 - Taylor & Francis
During the last decade, cell-penetrating peptides have been investigated for their ability to
overcome the plasma membrane barrier of mammalian cells for the intracellular or …

Recent advances in selective and targeted drug/gene delivery systems using cell-penetrating peptides

SH Nam, J Park, H Koo - Archives of Pharmacal Research, 2023 - Springer
Biological cell membranes are a natural barrier for living cells. In the last few decades, the
cell membrane has been the main hurdle in the efficient delivery of bioactive and therapeutic …

Cell-penetrating peptides with intracellular organelle targeting

CP Cerrato, K Künnapuu, Ü Langel - Expert opinion on drug …, 2017 - Taylor & Francis
Introduction: One of the major limiting steps in order to have an effective drug is the passage
through one or more cell membranes to reach its site of action. To reach the action-site, the …

On the biomedical promise of cell penetrating peptides: limits versus prospects

C Foerg, HP Merkle - Journal of pharmaceutical sciences, 2008 - Elsevier
The cell membrane poses a substantial hurdle to the use of pharmacologically active
biomacromolecules that are not per se actively translocated into cells. An appealing …