Synopsis Atorvastatin is a synthetic HMG-CoA reductase inhibitor which lowers plasma
cholesterol levels by inhibiting endogenous cholesterol synthesis. It also reduces …

Atorvastatin is a synthetic hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase
inhibitor. In dosages of 10 to 80 mg/day, atorvastatin reduces levels of total cholesterol, low …

Background Statins (3-hydroxy-3-methylglutaryl–coenzyme A [HMG-CoA] reductase
inhibitors) have been used for a decade to lower low-density lipoprotein (LDL) cholesterol …

Abstract This 6-week, double-blind clinical trial evaluated lipid parameter responses to
different dosages of atorvastatin in patients with primary hypercholesterolemia. Atorvastatin …

Simvastatin is an HMG-CoA reductase inhibitor used in the treatment of patients with
hypercholesterolaemia. Since the time simvastatin was previously reviewed in Drugs, a …

This analysis assessed the safety of atorvastatin in the 10-to 80-mg dose range using
pooled data from 44 completed trials comprising 16,495 dyslipidemic patients treated with …

The efficacy and safety of atorvastatin 10 mg versus simvastatin 20 mg and atorvastatin 80
mg versus simvastatin 80 mg was determined in a 6-week, prospective, randomized, open …

Plasma cholesterol and other lipoproteins play a significant role in the development of
atherosclerosis and subsequent coronary heart disease (CHD). This 1 year study was …

Synopsis Simvastatin (epistatin; synvinolin; MK 733), an HMG-CoA reductase inhibitor, acts
by decreasing cholesterol synthesis and by increasing low density lipoprotein (LDL) …

Hypercholesterolaemia is a risk factor for the development of atherosclerotic disease.
Atorvastatin lowers plasma low-density lipoprotein (LDL) cholesterol levels by inhibition of …