Genome-wide sequencing has led to the discovery of thousands of long non-coding RNA
(lncRNA) loci in the human genome, but evidence of functional significance has remained …

INTRODUCTION The human genome contains tens of thousands of loci that produce long
noncoding RNAs (lncRNAs), transcripts that have no apparent protein-coding potential. A …

Mammalian genomes contain thousands of loci that transcribe long noncoding RNAs
(lncRNAs),, some of which are known to carry out critical roles in diverse cellular processes …

Biological functions are known for only a small number of long non-coding RNAs (lncRNAs).
A study in Science now reports a highly specific, high-throughput CRISPR-based approach …

Recent genome-wide studies have revealed that the majority of the mouse genome is
transcribed as non-coding RNAs (ncRNAs) and growing evidence supports the importance …

The functions of many long noncoding RNAs (lncRNAs) in the human genome remain
unknown owing to the lack of scalable loss-of-function screening tools. We previously used …

Functional studies of long noncoding RNAs (lncRNAs) have been hindered by the lack of
methods to assess their evolution. Here we present lncRNA Homology Explorer (lncHOME) …

CRISPR–Cas9 screens have been widely adopted to analyze coding-gene functions, but
high-throughput screening of non-coding elements using this method is more challenging …

Prior to the sequencing of the human genome, it was presumed that most of the DNA coded
for proteins. However, with the advent of next-generation sequencing, it has now been …

Long non‐coding RNA s (lnc RNA s) have emerged as important regulators of cell biology.
The mechanisms by which lnc RNA s function are likely numerous, and most are poorly …