The mechanisms underlying operational tolerance after hematopoietic stem cell
transplantation in humans are poorly understood. We studied two independent cohorts of …

Although it is commonly accepted that allogeneic hematopoietic cell transplant (HCT)
recipients develop transplantation tolerance and can quickly discontinue all …

Biologic markers of immune tolerance may facilitate tailoring of immune suppression
duration after allogeneic hematopoietic cell transplantation (HCT). In a cross-sectional study …

Transplant rejection mediated by the adaptive immune system remains a major barrier to
achieving long-term tolerance and graft survival. Emerging evidence indicates that …

HLA incompatible organ transplant tolerance is the holy grail of transplantation. Stable
engraftment of an HLA mismatched allograft and life-long tolerance induction, though …

Operational tolerance (OT) after kidney transplantation is defined as stable graft acceptance
without the need for immunosuppression therapy. However, it is not clear which cellular and …

ABSTRACT Background/Objectives Immune reconstitution after allogeneic-hematopoietic-
stem-cell transplantation (allo-HSCT) is a complex and individual process. In this cross …

Metabolism, including catabolism and anabolism, is a basic cellular process necessary for
cell survival. T lymphocytes have a distinct metabolism that can determine both fate and …

The use of immunosuppressant drugs after organ transplantation has brought great success
in the field of organ transplantation with respect to short-term outcome. However, major …

There is increasing interest in transplantation of human stem cells for therapeutic purposes.
It would benefit future application if one could achieve their long-term acceptance and …