Polysaccharides from Polygonatum cyrtonema Hua prevent post-traumatic stress disorder behaviors in mice: mechanisms from the perspective of synaptic injury …

P Xie, L Chen, J Wang, X Wang, S Yang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance According to traditional Chinese medicine (TCM) theory,
post-traumatic stress disorder (PTSD) is a kind of depression syndrome, and its occurrence …

Polygonatum sibiricum polysaccharide prevents depression-like behaviors by reducing oxidative stress, inflammation, and cellular and synaptic damage

F Shen, Z Song, P Xie, L Li, B Wang, D Peng… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance According to traditional Chinese medicine (TCM) theory
(Yi Xue Zheng Zhuan), the main factors associated with the pathogenesis of depression are …

Polysaccharides from Polygonatum cyrtonema Hua Reduce Depression‐Like Behavior in Mice by Inhibiting Oxidative Stress‐Calpain‐1‐NLRP3 Signaling Axis

F Shen, P Xie, C Li, Z Bian, X Wang… - … Medicine and Cellular …, 2022 - Wiley Online Library
Polysaccharides from Polygonatum cyrtonema Hua (PSP) exert antioxidant, anti‐
inflammatory, and antidepressant effects. Production of reactive oxygen species (ROS) and …

Polygonatum sibiricum Polysaccharides Protect against MPP‐Induced Neurotoxicity via the Akt/mTOR and Nrf2 Pathways

S Huang, H Yuan, W Li, X Liu, X Zhang… - Oxidative medicine …, 2021 - Wiley Online Library
Polygonatum sibiricum, a well‐known life‐prolonging tonic in Chinese medicine, has been
widely used for nourishing nerves in the orient, but the underlying molecular mechanisms …

[HTML][HTML] Behavioral defects induced by chronic social defeat stress are protected by Momordica charantia polysaccharides via attenuation of JNK3/PI3K/AKT …

Z Deng, C Yuan, J Yang, Y Peng, W Wang… - Annals of …, 2019 - ncbi.nlm.nih.gov
Background The aim of this study was to evaluate the protective effects of Momordica
charantia polysaccharides (MCP) on depressive-like behaviors. Methods The chronic social …

Anshen Dingzhi prescription in the treatment of PTSD in mice: Investigation of the underlying mechanism from the perspective of hippocampal synaptic function

S Yang, Y Qu, J Wang, F Gao, M Ji, P Xie, A Zhu, B Tan… - Phytomedicine, 2022 - Elsevier
Abstract Background Anshen Dingzhi prescription (ADP) is an important prescription for the
treatment of mental diseases in traditional Chinese medicine and is widely used to treat …

[HTML][HTML] Gypenoside XVII, an active ingredient from gynostemma pentaphyllum, inhibits C3aR-associated synaptic pruning in stressed mice

MM Zhang, GM Huo, J Cheng, QP Zhang, NZ Li… - Nutrients, 2022 - mdpi.com
Gynostemma pentaphyllum is a herbal medicine widely used in Asian countries, and its
saponin extracts have been shown to possess potent anti-inflammatory effects. Gypenoside …

Polygonatum sibiricum polysaccharide inhibits high glucose-induced oxidative stress, inflammatory response, and apoptosis in RPE cells

W Wang, S Li, M Song - Journal of Receptors and Signal …, 2022 - Taylor & Francis
Diabetic retinopathy is one of the major diabetic complications and remains the most
common cause of adult blindness among patients with diabetes mellitus. Polygonatum …

BDNF-GSK-3β-β-Catenin Pathway in the mPFC Is Involved in Antidepressant-Like Effects of Morinda officinalis Oligosaccharides in Rats

LZ Xu, DF Xu, Y Han, LJ Liu, CY Sun… - International Journal …, 2017 - academic.oup.com
Background Morinda officinalis oligosaccharides have been reported to exert
neuroprotective and antidepressant-like effects in the forced swim test in mice. However, the …

Polygonum sibiricum polysaccharides exert the antidepressant‐like effects in chronic unpredictable mild stress‐induced depressive mice by modulating microbiota …

Y Zhang, Y Sun, Y Liu, J Liu, J Sun, X Liu… - Phytotherapy …, 2023 - Wiley Online Library
Polygonum sibiricum polysaccharides (PSP) are one of the main active components of
Polygonatum sibiricum, which is a traditional Chinese medicine with food and drug …