Delivery systems exploiting natural cell transport processes of macromolecules for intracellular targeting of Auger electron emitters

AA Rosenkranz, TA Slastnikova, GP Georgiev… - Nuclear Medicine and …, 2020 - Elsevier
The presence of Auger electrons (AE) among the decay products of a number of
radionuclides makes these radionuclides an attractive means for treating cancer because …

Modular nanotransporters for nuclear-targeted delivery of auger electron emitters

AS Sobolev - Frontiers in pharmacology, 2018 - frontiersin.org
This review describes artificial modular nanotransporters (MNTs) delivering their cargos into
target cells and then into the nuclei–the most vulnerable cell compartment for most …

Modular nanotransporters: a versatile approach for enhancing nuclear delivery and cytotoxicity of Auger electron-emitting 125I

TA Slastnikova, E Koumarianou, AA Rosenkranz… - EJNMMI research, 2012 - Springer
Background This study evaluates the potential utility of a modular nanotransporter (MNT) for
enhancing the nuclear delivery and cytotoxicity of the Auger electron emitter 125 I in cancer …

Auger radiation targeted into DNA: a therapy perspective

F Buchegger, F Perillo-Adamer, YM Dupertuis… - European journal of …, 2006 - Springer
Background Auger electron emitters that can be targeted into DNA of tumour cells represent
an attractive systemic radiation therapy goal. In the situation of DNA-associated decay, the …

Estimating the Relative Biological Effectiveness of Auger Electron Emitter 123I in Human Lymphocytes

H Fourie, S Nair, X Miles, D Rossouw, P Beukes… - Frontiers in …, 2020 - frontiersin.org
Auger electron emitters are considered to be a promising strategy for targeted radionuclide
therapy of metastatic diseases, given their high linear energy transfer (LET) and short range …

Auger electron emitters: insights gained from in vitro experiments

G Makrigiorgos, SJ Adelstein, AI Kassis - Radiation and environmental …, 1990 - Springer
This paper outlines the evolution of the current rationale for research into the biological
effects of tissue-incorporated Auger electron emitters. The first section is a brief review of the …

Targeted radiotherapy using Auger electron emitters

JA O'donoghue, TE Wheldon - Physics in Medicine & Biology, 1996 - iopscience.iop.org
Auger-emitting radionuclides have potential for the therapy of cancer due to their high level
of cytotoxicity and short-range biological effectiveness. Biological effects are critically …

Auger electrons: lethal, low energy, and coming soon to a tumor cell nucleus near you

CA Boswell, MW Brechbiel - Journal of Nuclear Medicine, 2005 - Soc Nuclear Med
Radiopharmaceuticals labeled with low-energy electron emitters have several key
advantages over traditional agents that emit higher-energy particles. Sadly, the majority of …

Antitumor Activity of Auger Electron Emitter 111In Delivered by Modular Nanotransporter for Treatment of Bladder Cancer With EGFR Overexpression

AA Rosenkranz, TA Slastnikova… - Frontiers in …, 2018 - frontiersin.org
Gamma-ray emitting 111In, which is extensively used for imaging, is also a source of short-
range Auger electrons (AE). While exhibiting negligible effect outside cells, these AE …

Auger electrons for cancer therapy–a review

A Ku, VJ Facca, Z Cai, RM Reilly - EJNMMI radiopharmacy and chemistry, 2019 - Springer
Abstract Background Auger electrons (AEs) are very low energy electrons that are emitted
by radionuclides that decay by electron capture (eg 111 In, 67 Ga, 99m Tc, 195m Pt, 125 I …