Restless legs syndrome (RLS) is a common sensorimotor disorder for which two main
pathological elements are fairly well accepted: Brain iron deficiency (BID) and an altered …

In this article, we review the original findings from MRI and autopsy studies that
demonstrated brain iron status is insufficient in individuals with restless legs syndrome …

Background Brain iron deficiency (BID), especially for the substantia nigra (SN), without
peripheral iron deficiency (ID) has been well documented as a ubiquitous finding for restless …

Restless legs syndrome (RLS) is clinically defined by the presence of (i) an urge to move the
legs with or without an actual paraesthesia;(ii) a worsening of symptoms with inactivity;(iii) …

Restless legs syndrome (RLS) is a common, chronic neurologic condition, which causes a
persistent urge to move the legs in the evening that interferes with sleep. Human and animal …

Restless legs syndrome is a neurological disorder characterized by an urgency to move the
legs during periods of rest. Data from a variety of sources provide a compelling argument …

Abstract Restless Legs Syndrome (RLS) is a disorder of sensation with a prevalence of
around 2–5% of the population. Relevant to understanding the possible pathophysiological …

Restless legs syndrome (RLS) is a common neurologic condition involving iron and
dopamine systems. We sought to create an animal model consistent with RLS based on …

A clear link exists between iron deficiency (ID) and nigrostriatal dopamine malfunction. This
link appears to play an important role in at least restless legs syndrome (RLS) if not several …

Brain iron deficiency (BID) constitutes a primary pathophysiological mechanism in restless
legs syndrome (RLS). BID in rodents has been widely used as an animal model of RLS …