At the beginning of ovarian aging, the ovulation of immature oocytes is accelerated, leading
to the arrest of ovulation despite the remaining oocytes. Here, RNA expression in the …

Background The decline in the quantity and quality of oocytes due to ovarian ageing in
women is now a significant threat to reproductive health today as the concept of delayed …

The ovary ages earlier than most other tissues, yet the underlying mechanisms remain
elusive. Here a comprehensive analysis of transcriptomic landscapes in different organs in …

Studying the molecular mechanisms of ovarian aging is crucial for understanding the age-
related fertility issues in females. Recently, a single-cell transcriptomic roadmap of ovarian …

Ovarian aging leads to diminished fertility, dysregulated endocrine signaling and increased
chronic disease burden. These effects begin to emerge long before follicular exhaustion …

Clinical and public health importance of reproductive aging is increasing as more women
delay attempts at childbearing. Moreover, the emotional, medical and social costs of …

Summary paragraph The ovary is the first organ to age in the human body, affecting both
fertility and overall health in women-. However, the biological mechanisms underlying …

Premature ovarian failure (POF) is a complex and heterogeneous disease that causes
infertility and subfertility. However, the molecular mechanism of POF has not been fully …

The molecular machinery of ovarian aging and female age-related pathway remain unclear.
Here, we utilized single-cell RNA-seq to profile over 9815 cells from both young and old …

The oocytes of female mammals will undergo aging after ovulation, also known as
postovulatory oocyte aging (POA). Until now, the mechanisms of POA have not been fully …