Qingchang Wenzhong Decoction ameliorates intestinal inflammation and intestinal barrier dysfunction in ulcerative colitis via the GC-C signaling pathway

Y Zhang, J Li, X Han, H Jiang, J Wang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Ulcerative colitis (UC) is an idiopathic, chronic
inflammatory disorder of the colonic mucosa, accompanied with abdominal pain, and bloody …

[HTML][HTML] Modified Zhenwu Decoction improved intestinal barrier function of experimental colitis through activation of sGC-mediated cGMP/PKG signaling

Y Xu, C Huang, H Xu, J Xu, KW Cheng, HL Mok… - Journal of …, 2024 - Elsevier
Background The invasion of luminal antigens and an aberrant immune response resulting
from a disrupted physical epithelial barrier are the key characteristics of ulcerative colitis …

An investigation into the HIF-dependent intestinal barrier protective mechanism of Qingchang Wenzhong decoction in ulcerative colitis management

M Yang, Y Zhang, Z Qiao, R Xu, S Chen, P Hu… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Ulcerative colitis (UC) is a chronic, non-specific
inflammatory disease affecting the colon and rectum with an etiology that remains elusive …

Huanglian Ganjiang decoction alleviates ulcerative colitis by restoring gut barrier via APOC1-JNK/P38 MAPK signal pathway based on proteomic analysis

YX He, YY Li, YQ Wu, LZ Ren, Y Wang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Ulcerative colitis (UC) is a kind of chronic intestinal
inflammation accompanied with abdominal pain, diarrhea and hematochezia. Huanglian …

Protective Effect of Qingchang Wenzhong Decoction on Colitis and Colitis-Related Carcinogenesis by Regulating Inflammation and Intestinal Fibrosis

Y Cheng, J Li, X Zhang, Y Li, X Shi, R Shi… - Journal of …, 2023 - Taylor & Francis
Purpose Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by
mucosal inflammation, which may develop into ulcerative colitis-associated carcinogenesis …

The potential mechanism of qinghua quyu jianpi decoction in the treatment of ulcerative colitis based on network pharmacology and experimental validation

F Qu, D Li, S Zhang, C Zhang, A Shen - Journal of Ethnopharmacology, 2023 - Elsevier
Ethnopharmacological relevance Ulcerative colitis (UC) is a chronic and recurrent
inflammation of the gastrointestinal tract. Following the idea of herbal property and …

Qingchang Wenzhong Decoction ameliorates dextran sulphate sodium‐induced ulcerative colitis in rats by downregulating the IP10/CXCR3 axis‐mediated …

T Mao, R Shi, W Zhao, Y Guo, K Gao… - Evidence‐Based …, 2016 - Wiley Online Library
Qingchang Wenzhong Decoction (QCWZD) is an effective traditional Chinese medicine
prescription. Our previous studies have shown that QCWZD has significant efficacy in …

Modified Gegen Qinlian decoction ameliorated ulcerative colitis by attenuating inflammation and oxidative stress and enhancing intestinal barrier function in vivo and …

Y Wang, J Zhang, B Zhang, M Lu, J Ma, Z Liu… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Modified Gegen Qinlian decoction (MGQD),
which was first documented in Treatise on Febrile Disease, is recognized as a classic …

Qingchang Wenzhong decoction accelerates intestinal mucosal healing through modulation of dysregulated gut microbiome, intestinal barrier and immune responses …

Z Sun, J Li, W Wang, Y Liu, J Liu, H Jiang… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel disease (IBD), a group of multifactorial and inflammatory infirmities, is
closely associated with dysregulation of gut microbiota and host metabolome, but effective …

Mechanism of Qingchang Suppository on repairing the intestinal mucosal barrier in ulcerative colitis

J Shan, S Liu, H Liu, J Yuan, J Lin - Frontiers in Pharmacology, 2023 - frontiersin.org
Ulcerative colitis (UC) is a refractory inflammatory bowel disease, and the outcomes of
conventional therapies of UC, including 5-aminosalicylic acid, glucocorticoids …