Sex differences in autophagy contribute to female vulnerability in Alzheimer's disease

EE Congdon - Frontiers in neuroscience, 2018 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia, with over 5. 4 million cases
in the US alone (Alzheimer's Association,). Clinically, AD is defined by the presence of …

Mechanisms of sex differences in Alzheimer's disease

C Lopez-Lee, ERS Torres, G Carling, L Gan - Neuron, 2024 - cell.com
Alzheimer's disease (AD) and the mechanisms underlying its etiology and progression are
complex and multifactorial. The higher AD risk in women may serve as a clue to better …

When Mars versus Venus is not a cliche: gender differences in the neurobiology of Alzheimer's disease

KA Lin, PM Doraiswamy - Frontiers in neurology, 2015 - frontiersin.org
Alzheimer's disease (AD) is a global public health threat with the prevalence projected to
triple over the next 50years. While substantial progress has been made in understanding the …

Sex differences in autophagy-mediated diseases: toward precision medicine

D Shang, L Wang, DJ Klionsky, H Cheng, R Zhou - Autophagy, 2021 - Taylor & Francis
Nearly all diseases in humans, to a certain extent, exhibit sex differences, including
differences in the onset, progression, prevention, therapy, and prognosis of diseases …

Sexual dimorphism in predisposition to Alzheimer's disease

DW Fisher, DA Bennett, H Dong - Neurobiology of aging, 2018 - Elsevier
Clinical studies indicate that Alzheimer's disease (AD) disproportionately affects women in
both disease prevalence and rate of symptom progression, but the mechanisms underlying …

Sex-biased autophagy as a potential mechanism mediating sex differences in ischemic stroke outcome

B Noh, LD McCullough… - Neural Regeneration …, 2023 - journals.lww.com
Stroke is the second leading cause of death and a major cause of disability worldwide, and
biological sex is an important determining factor in stroke incidence and pathology. From …

Female specific risk factors for the development of Alzheimer's disease neuropathology and cognitive impairment: Call for a precision medicine approach

C Udeh-Momoh, T Watermeyer - Ageing Research Reviews, 2021 - Elsevier
Alzheimer's disease (AD) includes a long asymptomatic stage, which precedes the formal
diagnosis of dementia. AD biomarker models provide a framework for precision medicine …

Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology

N Suelves, S Saleki, T Ibrahim, D Palomares… - Acta neuropathologica …, 2023 - Springer
Aging is the main risk factor for Alzheimer's disease (AD) and other neurodegenerative
pathologies, but the molecular and cellular changes underlying pathological aging of the …

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

MM Lipinski, B Zheng, T Lu, Z Yan… - Proceedings of the …, 2010 - National Acad Sciences
Dysregulation of autophagy, a cellular catabolic mechanism essential for degradation of
misfolded proteins, has been implicated in multiple neurodegenerative diseases. However …

Female sex and Alzheimer's risk: the menopause connection

O Scheyer, A Rahman, H Hristov, C Berkowitz… - The journal of …, 2018 - Springer
Along with advanced age and apolipoprotein E (APOE)-4 genotype, female sex is a major
risk factor for developing late-onset Alzheimer's disease (AD). Considering that AD …