The path of malaria vaccine development: challenges and perspectives

C Arama, M Troye‐Blomberg - Journal of internal medicine, 2014 - Wiley Online Library
Malaria is a life‐threatening disease caused by parasites of the P lasmodium genus. In
many parts of the world, the parasites have developed resistance to a number of antimalarial …

Vaccines for malaria: how close are we?

MA Thera, CV Plowe - Annual review of medicine, 2012 - annualreviews.org
Vaccines are the most powerful public health tools mankind has created, but malaria
parasites are bigger, more complicated, and wilier than the viruses and bacteria that have …

Steady progress toward a malaria vaccine

KE Lyke - Current Opinion in Infectious Diseases, 2017 - journals.lww.com
Vaccines are the most cost-effective tools to control infectious diseases, yet the complexity of
malaria has frustrated all attempts to develop an effective product. This review concentrates …

Vaccines against malaria

A Ouattara, MB Laurens - Clinical Infectious Diseases, 2015 - academic.oup.com
Despite global efforts to control malaria, the illness remains a significant public health threat.
Currently, there is no licensed vaccine against malaria, but an efficacious vaccine would …

Vaccines against malaria–an update

K Matuschewski, AK Mueller - The FEBS journal, 2007 - Wiley Online Library
Malaria vaccine discovery and development follow two principal strategies. Most subunit
vaccines are designed to mimic naturally acquired immunity that develops over years upon …

[HTML][HTML] Malaria vaccines and the new malaria agenda

BM Greenwood, GAT Targett - Clinical Microbiology and Infection, 2011 - Elsevier
The development of an effective malaria vaccine has taken many decades, but there is now
a good chance that the first malaria vaccine will be licensed within the next few years …

[PDF][PDF] Progress with new malaria vaccines

D Webster, AVS Hill - Bulletin of the World Health …, 2003 - SciELO Public Health
Malaria is a parasitic disease of major global health significance that causes an estimated
2.7 million deaths each year. In this review we describe the burden of malaria and discuss …

Progress toward a malaria vaccine: efficient induction of protective anti-malaria immunity

M Tsuji, EG Rodrigues, RS Nussenzweig - 2001 - degruyter.com
Malaria can be a very severe disease, particularly in young children, pregnant women
(mostly in primipara), and malaria naïve adults, and currently ranks among the most …

Progress towards the development of malaria vaccines

E Malkin, F Dubovsky, M Moree - Trends in parasitology, 2006 - cell.com
The misery and suffering caused worldwide by infection with the malaria parasite, especially
Plasmodium falciparum, has been well documented. Although no licensed vaccine against …

[HTML][HTML] Update on the clinical development of candidate malaria vaccines

WR Ballou, M Arevalo-Herrera, D Carucci… - … Intolerable Burden of …, 2004 - ncbi.nlm.nih.gov
The recent availability of significantly increased levels of funding for unmet medical needs in
the developing world, made available by newly created public-private-partnerships, has …