Exosome processing and characterization approaches for research and technology development

JJ Lai, ZL Chau, SY Chen, JJ Hill… - Advanced …, 2022 - Wiley Online Library
Exosomes are extracellular vesicles that share components of their parent cells and are
attractive in biotechnology and biomedical research as potential disease biomarkers as well …

Review on strategies and technologies for exosome isolation and purification

J Chen, P Li, T Zhang, Z Xu, X Huang… - … in bioengineering and …, 2022 - frontiersin.org
Exosomes, a nano-sized subtype of extracellular vesicles secreted from almost all living
cells, are capable of transferring cell-specific constituents of the source cell to the recipient …

Benchtop isolation and characterization of functional exosomes by sequential filtration

ML Heinemann, M Ilmer, LP Silva, DH Hawke… - … of Chromatography A, 2014 - Elsevier
Early and minimally invasive detection of malignant events or other pathologies is of utmost
importance in the pursuit of improved patient care and outcomes. Recent evidence indicates …

Exosomes: potential disease biomarkers and new therapeutic targets

MI Mosquera-Heredia, LC Morales, OM Vidal… - Biomedicines, 2021 - mdpi.com
Exosomes are extracellular vesicles released by cells, both constitutively and after cell
activation, and are present in different types of biological fluid. Exosomes are involved in the …

Challenges and opportunities in exosome research—Perspectives from biology, engineering, and cancer therapy

X Li, AL Corbett, E Taatizadeh, N Tasnim, JP Little… - APL …, 2019 - pubs.aip.org
ABSTRACT Exosomes are small ($30–140 nm) lipid bilayer-enclosed particles of
endosomal origin. They are a subset of extracellular vesicles (EVs) that are secreted by most …

Separation of distinct exosome subpopulations: isolation and characterization approaches and their associated challenges

K Singh, R Nalabotala, KM Koo, S Bose, R Nayak… - Analyst, 2021 - pubs.rsc.org
Exosomes are nano-sized extracellular vesicles that serve as a communications system
between cells and have shown tremendous promise as liquid biopsy biomarkers in …

Current status and outlook of advances in exosome isolation

W Liu, Z Ma, X Kang - Analytical and Bioanalytical Chemistry, 2022 - Springer
Exosomes are extracellular vesicles with a diameter ranging from 30 to 150 nm, which are
an important medium for intercellular communication and are closely related to the …

Exosome manufacturing status

W Whitford, P Guterstam - Future medicinal chemistry, 2019 - Taylor & Francis
Exosomes are secreted by mammalian cells and are widely distributed in cellular systems.
They are a medium of information and material transmission. The complexity of exosome …

Potential use of exosomes as diagnostic biomarkers and in targeted drug delivery: progress in clinical and preclinical applications

MN Huda, M Nafiujjaman, IG Deaguero… - ACS biomaterials …, 2021 - ACS Publications
Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …

Advances in exosome analysis

A Pallares-Rusiñol, M Bernuz, SL Moura… - Advances in clinical …, 2023 - Elsevier
There is growing demand for novel biomarkers that detect early stage disease as well as
monitor clinical management and therapeutic strategies. Exosome analysis could provide …