The RNA exosome complex constitutes the major nuclear eukaryotic 3′-5′ exonuclease.
Outside of nucleoli, the human nucleoplasmic exosome is directed to some of its substrates …

Abstract The Nuclear Exosome Targeting (NEXT) complex is a key cofactor of the
mammalian nuclear exosome in the removal of Promoter Upstream Transcripts (PROMPTs) …

The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate
targeting is facilitated by its co-factor Mtr4p/hMTR4, which links to RNA-binding protein …

The exosome complex is involved in multiple RNA processing and degradation pathways.
How exosome is recruited to particular RNA substrates and then chooses between RNA …

The RNA exosome is a conserved degradation machinery, which obtains full activity only
when associated with cofactors. The most prominent activator of the yeast nuclear exosome …

The exosome plays major roles in RNA processing and surveillance but the in vivo target
range and substrate acquisition mechanisms remain unclear. Here we apply in vivo RNA …

The exosome is a complex of 3′→ 5′ exoribonucleases which is involved in many RNA
metabolic processes. To regulate these functions distinct proteins are believed to recruit the …

The RNA exosome is a highly conserved ribonuclease endowed with 3′–5′ exonuclease
and endonuclease activities. The multisubunit complex resides in both the nucleus and the …

The RNA exosome processes and degrades RNAs in archaeal and eukaryotic cells.
Exosomes from yeast and humans contain two active exoribonuclease components, Rrp6p …

Mammalian genomes are promiscuously transcribed, yielding protein-coding and non-
coding products. Many transcripts are short lived due to their nuclear degradation by the …