Native metabolomics identifies the rivulariapeptolide family of protease inhibitors
The identity and biological activity of most metabolites still remain unknown. A bottleneck in
the exploration of metabolite structures and pharmaceutical activities is the compound …
the exploration of metabolite structures and pharmaceutical activities is the compound …
The “PepSAVI-MS” pipeline for natural product bioactive peptide discovery
CL Kirkpatrick, CA Broberg, EN McCool… - Analytical …, 2017 - ACS Publications
The recent increase in extensively drug-resistant bacterial pathogens and the associated
increase of morbidity and mortality demonstrate the immediate need for new antibiotic …
increase of morbidity and mortality demonstrate the immediate need for new antibiotic …
Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae
Natural product screening programs have uncovered molecules from diverse natural
sources with various biological activities and unique structures. However, much is yet …
sources with various biological activities and unique structures. However, much is yet …
A metabolomics guided exploration of marine natural product chemical space
DJ Floros, PR Jensen, PC Dorrestein, N Koyama - Metabolomics, 2016 - Springer
Introduction Natural products from culture collections have enormous impact in advancing
discovery programs for metabolites of biotechnological importance. These discovery efforts …
discovery programs for metabolites of biotechnological importance. These discovery efforts …
A silent biosynthetic gene cluster from a methanotrophic bacterium potentiates discovery of a substrate promiscuous proteusin cyclodehydratase
Natural product-encoding biosynthetic gene clusters (BGCs) within microbial genomes far
outnumber the known natural products; chemical products from such BGCs remain cryptic …
outnumber the known natural products; chemical products from such BGCs remain cryptic …
Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities
Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …
Automated genome mining of ribosomal peptide natural products
Ribosomally synthesized and posttranslationally modified peptides (RiPPs), especially from
microbial sources, are a large group of bioactive natural products that are a promising …
microbial sources, are a large group of bioactive natural products that are a promising …
DeepRiPP integrates multiomics data to automate discovery of novel ribosomally synthesized natural products
Microbial natural products represent a rich resource of evolved chemistry that forms the
basis for the majority of pharmacotherapeutics. Ribosomally synthesized and …
basis for the majority of pharmacotherapeutics. Ribosomally synthesized and …
MetaMiner: a scalable peptidogenomics approach for discovery of ribosomal peptide natural products with blind modifications from microbial communities
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are an
important class of natural products that contain antibiotics and a variety of other bioactive …
important class of natural products that contain antibiotics and a variety of other bioactive …
PepSAVI-MS reveals anticancer and antifungal cycloviolacins in Viola odorata
NC Parsley, CL Kirkpatrick, CM Crittenden, JG Rad… - Phytochemistry, 2018 - Elsevier
Widespread resistance to antimicrobial and cancer therapeutics is evolving in every country
worldwide and has a direct impact on global health, agriculture and the economy. The …
worldwide and has a direct impact on global health, agriculture and the economy. The …