Single‐cell transcriptomic analysis reveals circadian rhythm disruption associated with poor prognosis and drug‐resistance in lung adenocarcinoma

L He, Y Fan, Y Zhang, T Tu, Q Zhang… - Journal of Pineal …, 2022 - Wiley Online Library
Circadian rhythm disruption (CRD) represents a major contributor to tumor proliferation.
Nonetheless, the role of CRD in the clinical prediction of cancer outcomes has not been well …

[HTML][HTML] Circadian rhythm-associated clinical relevance and Tumor Microenvironment of Non-small Cell Lung Cancer

M Li, Z Chen, T Jiang, X Yang, Y Du, J Liang… - Journal of …, 2021 - ncbi.nlm.nih.gov
Objective: We aimed to explore the prognostic implication for non-small cell lung cancer
(NSCLC) based on the expression profiles of circadian clock-related genes (CCRGs), and …

[HTML][HTML] Circadian clock associates with tumor microenvironment in thoracic cancers

Y Yang, G Yuan, H Xie, T Wei, D Zhu, J Cui… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
The application of cancer chronotherapy is to treat cancers based on at specific times during
circadian rhythms. Previous studies have characterized the impact of circadian clock on …

Integrated multi-omics analysis reveals the molecular interplay between circadian clocks and cancer pathogenesis

A Pérez-Villa, G Echeverría-Garcés… - Scientific Reports, 2023 - nature.com
Circadian rhythms (CRs) are fundamental biological processes that significantly impact
human well-being. Disruption of these rhythms can trigger insufficient neurocognitive …

Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies

WH Chang, AG Lai - Journal of translational medicine, 2019 - Springer
Background The circadian clock governs a large variety of fundamentally important
physiological processes in all three domains of life. Consequently, asynchrony in …

Identification of TIMELESS and RORA as key clock molecules of non-small cell lung cancer and the comprehensive analysis

H Xian, Y Li, B Zou, Y Chen, H Yin, X Li, Y Pan - BMC cancer, 2022 - Springer
Background The incidence rate of non-small cell lung cancer (NSCLC) has been increasing
worldwide, and the correlation of circadian rhythm disruption with a raised risk of cancer and …

Circadian and immunity cycle talk in cancer destination: from biological aspects to in silico analysis

M Mirian, A Hariri, M Yadollahi, M Kohandel - Cancers, 2022 - mdpi.com
Simple Summary The circadian cycle is a natural cycle of the body repeated every 24 h,
based on a day and night rhythm, and it affects many body processes. The present article …

CRS: a circadian rhythm score model for predicting prognosis and treatment response in cancer patients

Y Liu, S Guo, Y Sun, C Zhang, J Gan, S Ning… - Journal of Translational …, 2023 - Springer
Background Circadian rhythm regulates complex physiological activities in organisms. A
strong link between circadian dysfunction and cancer has been identified. However, the …

Dysregulation, functional implications, and prognostic ability of the circadian clock across cancers

Z Liu, K Yu, J Zheng, H Lin, Q Zhao, X Zhang… - Cancer …, 2019 - Wiley Online Library
It has been proposed that the circadian rhythm generally plays important roles in tumor
suppression, but there is also evidence that disruption of the canonical circadian pathway …

[HTML][HTML] A circadian rhythm-related gene signature associated with tumor immunity, cisplatin efficacy, and prognosis in bladder cancer

R Zhou, X Chen, J Liang, Q Chen, H Tian… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Circadian dysregulation involves malignant tumor initiation and progression, but the
understanding of circadian rhythm's roles in bladder cancer (BCa) remains insufficient. The …