Mitochondrial dynamics and mitophagy in lung disorders

A Sharma, S Ahmad, T Ahmad, S Ali, MA Syed - Life sciences, 2021 - Elsevier
Mitochondria are biosynthetic, bioenergetic, and signaling organelles which are critical for
physiological adaptations and cellular stress responses to the environment. Various …

Mitochondrial dysfunction in chronic respiratory diseases: implications for the pathogenesis and potential therapeutics

W Zhou, J Qu, S Xie, Y Sun… - Oxidative Medicine and …, 2021 - Wiley Online Library
Mitochondria are indispensable for energy metabolism and cell signaling. Mitochondrial
homeostasis is sustained with stabilization of mitochondrial membrane potential, balance of …

Targeting the mitochondria in chronic respiratory diseases

DK Chellappan, KR Paudel, NW Tan, KS Cheong… - Mitochondrion, 2022 - Elsevier
Mitochondria are one of the basic essential components for eukaryotic life survival. It is also
the source of respiratory ATP. Recently published studies have demonstrated that …

Mitochondrial dysfunction in lung pathogenesis

CA Piantadosi, HB Suliman - Annual review of physiology, 2017 - annualreviews.org
Remarkable new roles for mitochondria in calcium handling, apoptosis, heme turnover,
inflammation, and oxygen and nutrient sensing have been discovered for organelles that …

Mitochondrial redox system, dynamics, and dysfunction in lung inflammaging and COPD

CA Lerner, IK Sundar, I Rahman - … journal of biochemistry & cell biology, 2016 - Elsevier
Myriad forms of endogenous and environmental stress disrupt mitochondrial function by
impacting critical processes in mitochondrial homeostasis, such as mitochondrial redox …

[HTML][HTML] Targeting mitochondrial dysfunction in lung diseases: emphasis on mitophagy

A Sureshbabu, V Bhandari - Frontiers in physiology, 2013 - frontiersin.org
During mild stressful conditions, cells activate a multitude of mechanisms in an attempt to
repair or re-establish homeostasis. One such mechanism is autophagic degradation of …

Mitochondria in chronic obstructive pulmonary disease and lung cancer: where are we now?

HS Nam, E Izumchenko, S Dasgupta… - Biomarkers in …, 2017 - Taylor & Francis
Recent advances in mitochondrial biogenesis have provided the emerging recognition that
mitochondria do much more than 'simply providing energy for cellular function'. Currently, a …

Mitochondrial dysfunction in airway disease

YS Prakash, CM Pabelick, GC Sieck - Chest, 2017 - Elsevier
There is increasing appreciation that mitochondria serve cellular functions beyond oxygen
sensing and energy production. Accordingly, it has become important to explore …

Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease

M Aghapour, AHV Remels… - … of Physiology-Lung …, 2020 - journals.physiology.org
Disturbances in mitochondrial structure and function in lung epithelial cells have been
implicated in the pathogenesis of various lung diseases, including chronic obstructive …

Mitochondrial dysfunction in inflammatory responses and cellular senescence: pathogenesis and pharmacological targets for chronic lung diseases

L Yue, H Yao - British journal of pharmacology, 2016 - Wiley Online Library
Mitochondria are dynamic organelles, which couple the various cellular processes that
regulate metabolism, cell proliferation and survival. Environmental stress can cause …