3A5. The distribution of the common variant alleles of CYP genes varies among different
ethnic populations. Pharmacogenetics has the potential to achieve optimal quality use of …

Pharmacogenetics represents a rapidly advancing, competitive field of investigation. Due to
the potential for clinically recognizable interactions between a set of old polymorphic genes …

Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Variability in drug response can be attributed in part to variability in the activity of drug–
metabolizing enzymes. One of the most important drugmetabolizing enzyme systems in …

Members of the human cytochrome P450 (CYP) superfamily play a role in the metabolism of
many drugs and several of them, CYP2D6, CYP2C9 and CYP2C19, have been shown to be …

The field of cytochrome P450 pharmacogenetics has progressed rapidly during the past 25
years. All the major human drug-metabolizing P450 enzymes have been identified and …

Pharmacogenetics (or pharmacogenomics) studies the role of inherited and acquired
genetic variation in drug response. Clinically relevant pharmacogenetic examples, mainly …

Inter‐individual variability in drug metabolism results from the influence of a myriad of
factors, such as concomitant drug therapy and genetic factors. Advances in recombinant …

The goal of drug therapy has always been to achieve optimal drug efficacy and safety for
every individual. Although pharmacotherapy has come far, this goal remains elusive. From a …

Polymorphisms in genes encoding cytochrome P450 s (CYPs) cause interindividual
variability in the metabolism of a wide range of structurally diverse substrates including …