Drug addiction is widely recognized to afflict some but not all individuals by virtue of
underlying risk markers and traits involving multifaceted interactions between polygenic and …

Drug addiction is a complex neuropsychiatric disorder that affects a subset of the individuals
who take drugs. It is characterized by maladaptive drug-seeking habits that are maintained …

This article reviews recent advances in the elucidation of neurobehavioral endophenotypes
associated with drug addiction made possible by the translational neuroimaging techniques …

Substance use disorders continue to impose increasing medical, financial and emotional
burdens on society in the form of morbidity and overdose, family disintegration, loss of …

Addictions are prevalent psychiatric disorders that confer remarkable personal and social
burden. Despite substantial evidence for their moderate, yet robust, heritability (approx …

Drug addiction involves long-term behavioral abnormalities that arise in response to
repeated exposure to drugs of abuse in vulnerable individuals. It is a multifactorial syndrome …

Drug addiction is a neuropsychiatric disorder with grave personal consequences that has an
extraordinary global economic impact. Despite decades of research, the options available to …

Rates of return to use in addiction treatment remain high. We argue that the development of
improved treatment options will require advanced understanding of individual heterogeneity …

A major challenge in understanding substance-use disorders lies in uncovering why some
individuals become addicted when exposed to drugs, whereas others do not. Although …

Incentive salience, negative emotionality, and executive function are functional domains that
are etiologic in the initiation and progression of addictive disorders, having been implicated …