Detection of the WT1 transcript by RT-PCR in complete remission has no prognostic relevance in de novo acute myeloid leukemia
A Gaiger, D Schmid, G Heinze, B Linnerth, H Greinix… - Leukemia, 1998 - nature.com
The WT1 gene is expressed in 73–100% of patients with acute myelogenous leukemia
(AML) and is thought to play a role in maintaining the viability of leukemic cells. WT1 has …
(AML) and is thought to play a role in maintaining the viability of leukemic cells. WT1 has …
Prognostic significance of WT1 gene expression at diagnosis in adult de novo acute myeloid leukemia
We examined the presence of WT1-specific mRNA in bone marrow samples of 125 patients
with de novo acute myeloid leukemia at diagnosis by two-step RT-PCR. The sensitivity of the …
with de novo acute myeloid leukemia at diagnosis by two-step RT-PCR. The sensitivity of the …
Quantitative assessment of WT1 gene expression after allogeneic stem cell transplantation is a useful tool for monitoring minimal residual disease in acute myeloid …
A Candoni, M Tiribelli, E Toffoletti… - European journal of …, 2009 - Wiley Online Library
Introduction: WT1 overexpression is described in several oncological diseases including
acute myeloid leukemia (AML). Quantification of WT1 in bone marrow samples may be …
acute myeloid leukemia (AML). Quantification of WT1 in bone marrow samples may be …
Quantitative assessment of WT1 expression by real time quantitative PCR may be a useful tool for monitoring minimal residual disease in acute leukemia patients
D Cilloni, E Gottardi, D De Micheli, A Serra, G Volpe… - Leukemia, 2002 - nature.com
In order to verify if quantitative assessment of the WT1 transcript amount by the real time
quantitative PCR (RQ-PCR) can be used as a marker for minimal residual disease detection …
quantitative PCR (RQ-PCR) can be used as a marker for minimal residual disease detection …
Prognostic significance of quantitative analysis of WT1 gene transcripts by competitive reverse transcription polymerase chain reaction in acute leukaemia
M Garg, H Moore, K Tobal… - British journal of …, 2003 - Wiley Online Library
We have developed a sensitive, competitive, nested reverse transcription polymerase chain
reaction (RT‐PCR) titration assay that quantifies the number of Wilm's tumour (WT1) gene …
reaction (RT‐PCR) titration assay that quantifies the number of Wilm's tumour (WT1) gene …
WT1 expression as a marker of minimal residual disease predicts outcome in acute myeloid leukemia when measured post-consolidation
WT1 levels may be a useful predictor of leukemia free survival (LFS) following treatment of
acute myeloid leukemia (AML). We report a retrospective study in which levels of WT1 …
acute myeloid leukemia (AML). We report a retrospective study in which levels of WT1 …
The detection of wt-1 transcripts is not associated with an increased leukemic relapse rate in patients with acute leukemia after allogeneic bone marrow or peripheral …
AH Elmaagacli, DW Beelen, R Trenschel… - Bone marrow …, 2000 - nature.com
We studied the role of wt-1 as a minimal residual disease (MRD) marker in 46 patients with
acute leukemia (AL)(1st CR n= 24; 2nd CR n= 9, in relapse n= 13) after allogeneic bone …
acute leukemia (AL)(1st CR n= 24; 2nd CR n= 9, in relapse n= 13) after allogeneic bone …
WT1 as a new prognostic factor and a new marker for the detection of minimal residual disease in acute leukemia
K Inoue, H Sugiyama, H Ogawa, M Nakagawa… - 1994 - ashpublications.org
The WT1 gene encoding a zinc finger polypeptide is a tumor suppressor gene that plays a
key role in the carcinogenesis of Wilms' tumor. Reverse transcriptase-polymerase chain …
key role in the carcinogenesis of Wilms' tumor. Reverse transcriptase-polymerase chain …
Prognostic impact of RT-PCR-based quantification of WT1 gene expression during MRD monitoring of acute myeloid leukemia
M Weisser, W Kern, S Rauhut, C Schoch… - Leukemia, 2005 - nature.com
In search for general PCR targets for minimal residual disease (MRD) studies in acute
myeloid leukemia (AML), Wilms' tumor gene 1 (WT1) expression was assessed by real-time …
myeloid leukemia (AML), Wilms' tumor gene 1 (WT1) expression was assessed by real-time …
Early detection of WT1 measurable residual disease identifies high-risk patients, independent of transplantation in AML
J Lambert, J Lambert, X Thomas… - Blood …, 2021 - ashpublications.org
WT1 overexpression is frequently identified in acute myeloid leukemia (AML) and has been
reported to be a potential marker for monitoring measurable residual disease (MRD). We …
reported to be a potential marker for monitoring measurable residual disease (MRD). We …
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