Natural killer cell homing and trafficking in tissues and tumors: from biology to application

GH Ran, YQ Lin, L Tian, T Zhang, DM Yan… - Signal transduction and …, 2022 - nature.com
Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …

The changing role of natural killer cells in cancer metastasis

IS Chan, AJ Ewald - The Journal of clinical investigation, 2022 - Am Soc Clin Investig
Natural killer (NK) cells are innate immune cells that are critical to the body's antitumor and
antimetastatic defense. As such, novel therapies are being developed to utilize NK cells as …

Natural killer cell adoptive transfer therapy: exploiting the first line of defense against cancer

ZB Davis, M Felices, MR Verneris, JS Miller - The Cancer Journal, 2015 - journals.lww.com
Natural killer (NK) cells constitute an important component of the initial immunological
response against transformed cells. However, chronic exposure to the tumor …

Advantages and clinical applications of natural killer cells in cancer immunotherapy

E Ames, WJ Murphy - Cancer Immunology, Immunotherapy, 2014 - Springer
The past decade has witnessed a burgeoning of research and further insight into the biology
and clinical applications of natural killer (NK) cells. Once thought to be simple innate cells …

Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders

NA Maskalenko, D Zhigarev… - Nature reviews Drug …, 2022 - nature.com
Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and
viral infections. They are 'first responders' that can spontaneously recognize abnormal cells …

Targeting natural killer cells and natural killer T cells in cancer

E Vivier, S Ugolini, D Blaise, C Chabannon… - Nature Reviews …, 2012 - nature.com
Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share
some phenotypical and functional similarities. Both cell types can rapidly respond to the …

Natural killer cells in human cancer: from biological functions to clinical applications

EM Levy, MP Roberti, J Mordoh - BioMed Research …, 2011 - Wiley Online Library
Natural killer (NK) cells are central components of the innate immunity. In murine models, it
has been shown that NK cells can control both local tumor growth and metastasis due to …

Challenges to the broad application of allogeneic natural killer cell immunotherapy of cancer

PR Kennedy, M Felices, JS Miller - Stem Cell Research & Therapy, 2022 - Springer
Natural killer (NK) cells are innate immune cells that recognize malignant cells through a
wide array of germline-encoded receptors. Triggering of activating receptors results in …

Targeting natural killer cells in cancer immunotherapy

C Guillerey, ND Huntington, MJ Smyth - Nature immunology, 2016 - nature.com
Alteration in the expression of cell-surface proteins is a common consequence of malignant
transformation. Natural killer (NK) cells use an array of germline-encoded activating and …

[HTML][HTML] Natural killer cell-based therapies targeting cancer: possible strategies to gain and sustain anti-tumor activity

CIM Dahlberg, D Sarhan, M Chrobok, AD Duru… - Frontiers in …, 2015 - frontiersin.org
Natural killer (NK) cells were discovered 40 years ago, by their ability to recognize and kill
tumor cells without the requirement of prior antigen exposure. Since then, NK cells have …