Macrophages are conventionally classified into M1 and M2 subtypes according to their
differentiation status and functional role in the immune system. However, accumulating …

Macrophages play an important role in tissue development and homeostasis. They serve as
a nexus between adaptive and innate immunity, and employ considerable plasticity. In …

Macrophages are critical regulators of tissue homeostasis but are also abundant in the
tumor microenvironment (TME). In both primary tumors and metastases, such tumor …

The fact that various immune cells, including macrophages, can be found in tumor tissues
has long been known. With the introduction of concept that macrophages differentiate into a …

Macrophages sustain tumour progression by facilitating angiogenesis, promoting
immunosuppression, and enhancing cancer cell invasion and metastasis. They also …

Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …

Tumor‐associated macrophages (TAMs) are key components of the tumor
macroenvironment. Cancer‐and host cell‐derived signals generally drive the functions of …

Long recognized as an evolutionarily ancient cell type involved in tissue homeostasis and
immune defense against pathogens, macrophages are being re-discovered as regulators of …

Macrophages are the phagocytic sentinel cells of our body, with high plasticity required to
maintain homeostasis. This incredibly diverse set of cells, in response to various …

Macrophages are heterogeneous cells that present as different functional phenotypes due to
their plasticity. They can be classified into two categories, namely M1-and M2-like …