Oligodendrocytes (OLs) are particularly susceptible to the toxicity of the acute lesion
environment after spinal cord injury (SCI). They undergo both necrosis and apoptosis …

Spinal cord injury (SCI) affects over 17,000 individuals in the United States per year,
resulting in sudden motor, sensory and autonomic impairments below the level of injury …

Adult progenitor cells proliferate in the acutely injured spinal cord and their progeny
differentiate into new oligodendrocytes (OLs) that remyelinate spared axons. Whether this …

Oligodendrocyte progenitor cells (OPCs) are the most proliferative and dispersed population
of progenitor cells in the adult central nervous system, which allows these cells to rapidly …

Myelin is a proteolipid sheath enwrapping axons in the nervous system that facilitates signal
transduction along the axons. In the central nervous system (CNS), oligodendrocytes are …

Oligodendrocyte (OL) loss and axon demyelination occur after spinal cord injury (SCI). OLs
may be replaced, however, by proliferating NG2+ progenitor cells. Indeed, new OLs have …

Spinal cord injury (SCI) is a devastating condition to individuals, families, and society.
Oligodendrocyte loss and demyelination contribute as major pathological processes of …

Spinal cord injury (SCI) is a major cause of disability, and at present, there is no universally
accepted treatment. The functional decline following SCI is contributed to both direct …

Glial cell types were classified less than 100 years ago by del Rio-Hortega. For instance, he
correctly surmised that microglia in pathologic central nervous system (CNS) were …

Myelin integrity is crucial for central nervous system (CNS) physiology while its preservation
and regeneration after spinal cord injury (SCI) is key to functional restoration. Disturbance of …