Accumulating evidence demonstrates that metabolic changes in the brain associated with
neuroinflammation, oxidative stress, and mitochondrial dysfunction play an important role in …

Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

Background Alzheimer's disease (AD) is the commonest cause of dementia, with
approximately 5 million new cases occurring annually. Despite decades of research, its …

Alzheimer's disease (AD) is a neurodegenerative disease that affects millions of people
worldwide. Currently, there is no effective treatment for AD, which indicates the necessity to …

Significance: Epidemiological studies indicate that metabolic disorders are associated with
an increased risk for Alzheimer's disease (AD). Metabolic remodeling occurs in the central …

The complexities that underlie the cognitive impairment and neurodegeneration
characteristic of Alzheimer's disease (AD) have yet to be completely understood, although …

Oxidative and nitrosative stress are widely recognized as critical factors in the pathogenesis
and progression of Alzheimer disease (AD) and its earlier stage, amnestic mild cognitive …

Synapses are sites of high energy demand which are dependent on high levels of
mitochondrial derived adenosine triphosphate. Mitochondria within synaptic structures are …

Alzheimer's disease (AD) is a multifactorial disorder characterized by the progressive
deterioration of neuronal networks. The primary cause and sequence of its progression are …

Alzheimer's disease (AD), the most common form of dementia, has increasing incidence,
increasing mortality rates, and poses a huge burden on healthcare. None of the currently …