Abstract Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of
programmed cell death discovered and investigated in recent years. There are already …

Neuroinflammation is a complex inflammatory process in the nervous system that is
expected to play a significant role in neurological diseases. Necroptosis is a kind of necrosis …

Background Programmed necrosis/necroptosis is an emerging form of cell death that plays
important roles in mammalian development and the immune system. The pro-necrotic …

Necroptosis is a type of regulated cell death dependent on the activity of receptor-interacting
serine/threonine-protein (RIP) kinases. However, unlike apoptosis, it is caspase …

The family of death receptors plays a critical role in regulating cell number and eliminating
harmful or virally infected cells. Agonistic stimulation of death receptors is known to lead two …

Necrostatin-5 (Nec-5) is a novel potent small-molecule inhibitor of necroptosis structurally
distinct from previously described Necrostatin-1 (Nec-1), and therefore, represents a new …

Necrosis plays an important role in multiple physiological and pathological processes.
Recently, a relatively new form of necrosis has been characterized as “necroptosis” …

Necroptosis is a regulated caspase-independent cell death mechanism characterized by
morphological features resembling non-regulated necrosis. Necrotatin-7 (Nec-7), a novel …

Necroptosis has emerged as an important form of regulated necrotic cell death, which can
occur during mouse development and is also an important contributor to necrotic tissue …

As an important type of programmed cell death in addition to apoptosis, necroptosis occurs
in a variety of pathophysiological processes, including infections, liver diseases, kidney …