The low-density-lipoprotein receptor (LDLr) removes low-density lipoprotein (LDL), an
endovascular transporter that carries cholesterol from the bloodstream to peripheral tissues …

Background: Evidence has revealed an association between familial hypercholesterolemia
and cognitive impairment. In this regard, a connection between cognitive deficits and …

Convergent epidemiological, clinical, and experimental findings indicate that
hypercholesterolemia contributes to the onset of Alzheimer's disease (AD)-like dementia, but …

Aging continues to be the main cause of the development of Alzheimer's, although it has
been described that certain chronic inflammatory pathologies can negatively influence the …

Background Evidence from clinical studies support the fact that abnormal cholesterol
metabolism in the brain leads to progressive cognitive dysfunction. The low-density …

Lipoproteins are the complexes of different lipids and proteins, which are devoted to the
transport and clearance of lipids or lipid‐related molecules in the circulation. Lipoproteins …

The low-density lipoprotein receptor (LDLr) plays a crucial role in the regulation of
cholesterol levels in the blood by mediating the vascular uptake and intracellular …

Lipoproteins in the central nervous system (CNS) are not incorporated from the blood but
are formed mainly by glial cells within the CNS. In addition, cholesterol in the CNS is …

The metabolic syndrome is a cluster of common pathologies: abdominal obesity linked to an
excess of visceral fat, insulin resistance, dyslipidemia and hypertension. At the molecular …

Alzheimer's disease (AD) and other classes of dementia are important public health
problems with overwhelming social, physical, and financial effects for patients, society, and …