Microsatellite expansions cause a number of dominantly-inherited neurological diseases.
Expansions in coding-regions cause protein gain-of-function effects, while non-coding …

Trinucleotide expansions cause disease by both protein-and RNA-mediated mechanisms.
Unexpectedly, we discovered that CAG expansion constructs express homopolymeric …

We previously reported that a (CTG) n expansion causes spinocerebellar ataxia type 8
(SCA8), a slowly progressive ataxia with reduced penetrance. We now report a transgenic …

Spinocerebellar ataxia type 3 is one of the polyglutamine (polyQ) diseases, which are
caused by a CAG-repeat expansion within the coding region of the associated genes. The …

Abstract Spinocerebellar ataxia type 8 (SCA 8) is caused by a bidirectionally transcribed
CTG· CAG expansion that results in the in vivo accumulation of CUG RNA foci, an ATG …

Polyglutamine (polyQ) diseases, including several types of spinocerebellar ataxias and
Huntington's disease (HD), are dominantly inherited neurodegenerative disorders caused …

The dominant ataxias, also known as spinocerebellar ataxias, continue to grow in number.
Here we review the major categories of spinocerebellar ataxias: expanded polyglutamine …

Polyglutamine (polyQ) diseases are a class of dominantly inherited neurodegenerative
disorders caused by the expansion of a CAG repeat encoding glutamine within the coding …

Spinocerebellar ataxia type 3 (SCA3) is a currently incurable neurodegenerative disorder
caused by a CAG triplet expansion in exon 10 of the ATXN3 gene. The resultant expanded …

Several inherited neurodegenerative disorders are caused by CAG trinucleotide repeat
expansions, which can be located either in the coding region or in the untranslated region …