Delayed CO2 postconditioning promotes neurological recovery after cryogenic traumatic brain injury by downregulating IRF7 expression

Y Li, R Chen, GP Shen, J Yin, Y Li… - CNS Neuroscience …, 2023 - Wiley Online Library
Aims Few treatments are available in the subacute phase of traumatic brain injury (TBI)
except rehabilitation training. We previously reported that transient CO2 inhalation applied …

Hypoxic postconditioning drives protective microglial responses and ameliorates white matter injury after ischemic stroke

W Zhang, S Li, HJ Yun, W Yu, W Shi… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Ischemic stroke (IS) is a cerebrovascular disease with high incidence and
mortality. White matter repair plays an important role in the long‐term recovery of …

Hypoxic postconditioning‑induced neuroprotection increases neuronal autophagy via activation of the SIRT1/FoxO1 signaling pathway in rats with global cerebral …

J Liu, Z Gong, J Wu, S Liu, X Wang… - Experimental and …, 2021 - spandidos-publications.com
Hypoxic postconditioning (HPC) has been reported to be a beneficial and promising
treatment for global cerebral ischemia (GCI). However, its neuroprotective mechanism …

Delayed Chronic Acidic Postconditioning Improves Poststroke Motor Functional Recovery and Brain Tissue Repair by Activating Proton-Sensing TDAG8

YY Fan, Y Li, XY Tian, YJ Wang, J Huo, BL Guo… - Translational Stroke …, 2023 - Springer
Acidic postconditioning by transient CO2 inhalation applied within minutes after reperfusion
has neuroprotective effects in the acute phase of stroke. However, the effects of delayed …

Prophylactic treatment of hyperbaric oxygen treatment mitigates inflammatory response via mitochondria transfer

T Lippert, CV Borlongan - CNS neuroscience & therapeutics, 2019 - Wiley Online Library
Aims Hyperbaric oxygen therapy (HBOT) has been widely used as postinjury treatment;
however, we investigate its ability to mitigate potential damage as a preconditioning option …

Hypoxic postconditioning activates the Wnt/β‐catenin pathway and protects against transient global cerebral ischemia through Dkk1 inhibition and GSK‐3β …

L Zhan, D Liu, H Wen, J Hu, T Pang, W Sun… - The FASEB …, 2019 - Wiley Online Library
ABSTRACT The Wingless/Int (Wnt)/β‐catenin pathway plays an essential role in cell
survival. Although post‐conditioning with 8% oxygen can alleviate transient global cerebral …

cPKCγ-Modulated Autophagy Contributes to Ischemic Preconditioning–Induced Neuroprotection in Mice with Ischemic Stroke via mTOR-ULK1 Pathway

Y Zhang, L Ma, Y Yan, L Zhao, S Han, D Wu… - Translational Stroke …, 2023 - Springer
Neuron-specific conventional protein kinase C (cPKC) γ mediates cerebral hypoxic
preconditioning (HPC). In parallel, autophagy plays a prosurvival role in ischemic …

Hyperbaric oxygen preconditioning attenuates neuroinflammation after intracerebral hemorrhage in rats by regulating microglia characteristics

L Yang, J Tang, Q Chen, B Jiang, B Zhang, Y Tao, L Li… - Brain research, 2015 - Elsevier
Intracerebral Hemorrhage (ICH) results in a detrimental neurologic disorder with
complicated secondary brain injury. Hyperbaric oxygen preconditioning (HBOP) may be a …

Selective brain cooling reduces motor deficits induced by combined traumatic brain injury, hypoxemia and hemorrhagic shock

LY Leung, K Cardiff, X Yang… - Frontiers in …, 2018 - frontiersin.org
Selective brain cooling (SBC) can potentially maximize the neuroprotective benefits of
hypothermia for traumatic brain injury (TBI) patients without the complications of whole body …

Remote limb ischemic postconditioning inhibits microglia pyroptosis by modulating HGF after acute ischemia stroke

L Yu, Z Zhang, H Chen, M Wang, W Mao… - Bioengineering & …, 2023 - Wiley Online Library
The repetitive inflation–deflation of a blood pressure cuff on a limb is known as remote limb
ischemic postconditioning (RIPostC). It prevents brain damage induced by acute ischemia …