Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt's
expression in most immune cells, either at baseline or upon activation, reflects its …

The critical roles of kinase AKT in tumour cell proliferation, apoptosis and protein synthesis
have been widely recognized. But AKT also plays an important role in immune modulation …

Akt (protein kinase B) is a serine/threonine protein kinase that regulates cell metabolism,
survival and proliferation. Recent studies of the role of Akt in phagocytosis, intracellular …

Autoimmunity affects a substantial fraction of our population. In patients with autoimmune
disease, the immune system recognizes self-tissues as foreign. Common autoimmune …

The serine/threonine kinases of the Akt/protein kinase B family are regulated in part by
recruitment to the plasma membrane, which is accomplished by the binding of an N-terminal …

Akt kinases translate various external cues into intracellular signals that control cell survival,
proliferation, metabolism and differentiation. This review discusses the requirement for Akt …

Macrophages become activated initiating innate immune responses. Depending on the
signals, macrophages obtain an array of activation phenotypes, described by the broad …

The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical
signaling molecule within eukaryotic cells. Significant progress has been made in clarifying …

Protein kinase (PK) Cθ and Akt/PKBα cooperate in T cell receptor/CD28-induced T cell
signaling. We here demonstrate the recruitment of endogenous Akt1 and PKCθ to lipid rafts …

The Ser and Thr kinase AKT, also known as protein kinase B (PKB), was discovered 25
years ago and has been the focus of tens of thousands of studies in diverse fields of biology …