[HTML][HTML] Alzheimer disease: an update on pathobiology and treatment strategies
JM Long, DM Holtzman - Cell, 2019 - cell.com
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …
Challenges for Alzheimer's disease therapy: insights from novel mechanisms beyond memory defects
Alzheimer's disease (AD), the most common form of dementia in late life, will become even
more prevalent by midcentury, constituting a major global health concern with huge …
more prevalent by midcentury, constituting a major global health concern with huge …
Alzheimer's disease: the right drug, the right time
Alzheimer's disease (AD) is an age-associated neurodegenerative disease that is reaching
epidemic proportions as a result of the aging of the world's population. Impressive gains in …
epidemic proportions as a result of the aging of the world's population. Impressive gains in …
Potential Therapeutic Strategies for Alzheimer's Disease Targeting or Beyond β‐Amyloid: Insights from Clinical Trials
Q Jia, Y Deng, H Qing - BioMed research international, 2014 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with two hallmarks: β‐
amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly …
amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly …
Alzheimer's disease: the challenge of the second century
DM Holtzman, JC Morris, AM Goate - Science translational medicine, 2011 - science.org
Alzheimer's disease (AD) was first described a little more than 100 years ago. It is the most
common cause of dementia with an estimated prevalence of 30 million people worldwide, a …
common cause of dementia with an estimated prevalence of 30 million people worldwide, a …
Alzheimer disease
DS Knopman, H Amieva, RC Petersen… - Nature reviews Disease …, 2021 - nature.com
Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …
Current perspectives on pharmacotherapy of Alzheimer's disease
K Chopra, S Misra, A Kuhad - Expert opinion on pharmacotherapy, 2011 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is a daunting public health threat that has prompted
the scientific community's ongoing efforts to decipher the underlying disease mechanism …
the scientific community's ongoing efforts to decipher the underlying disease mechanism …
Recent therapeutic strategies targeting beta amyloid and tauopathies in Alzheimer's disease
Y Madav, S Wairkar, B Prabhakar - Brain research bulletin, 2019 - Elsevier
Alzheimer's disease (AD) has been a global concern for years due to its severe implications
that affects the quality of life of the patients. The available line of therapy for treating …
that affects the quality of life of the patients. The available line of therapy for treating …
Advances in developing novel therapeutic strategies for Alzheimer's disease
J Cao, J Hou, J Ping, D Cai - Molecular neurodegeneration, 2018 - Springer
Abstract Alzheimer's Disease (AD), the most prevalent neurodegenerative disease of aging,
affects one in eight older Americans. Nearly all drug treatments tested for AD today have …
affects one in eight older Americans. Nearly all drug treatments tested for AD today have …
Amyloid-β-independent regulators of tau pathology in Alzheimer disease
R van der Kant, LSB Goldstein… - Nature Reviews …, 2020 - nature.com
The global epidemic of Alzheimer disease (AD) is worsening, and no approved treatment
can revert or arrest progression of this disease. AD pathology is characterized by the …
can revert or arrest progression of this disease. AD pathology is characterized by the …