Immunological functions of the omentum

S Meza-Perez, TD Randall - Trends in immunology, 2017 - cell.com
The omentum is a visceral adipose tissue with unique immune functions. Although it is
primarily an adipose tissue, the omentum also contains lymphoid aggregates, called milky …

Specialized immune responses in the peritoneal cavity and omentum

M Liu, A Silva-Sanchez, TD Randall… - Journal of Leucocyte …, 2021 - academic.oup.com
The peritoneal cavity is a fluid filled space that holds most of the abdominal organs,
including the omentum, a visceral adipose tissue that contains milky spots or clusters of …

Lymphocytes in the peritoneum home to the omentum and are activated by resident dendritic cells

DA Carlow, MR Gold, HJ Ziltener - The Journal of Immunology, 2009 - journals.aai.org
The omentum is of interest in the context of obesity-related metabolic disease where
adipose tissue exhibits inflammatory changes; however, the immunology of the omentum is …

Omental immune aggregates and tumor metastasis within the peritoneal cavity

EW Sorensen, SA Gerber, AL Sedlacek… - Immunologic …, 2009 - Springer
The omentum, an important peritoneal tissue, is studded with a high number of immune
aggregates, or “milky spots,” the number, function, and phenotype of which is largely …

[PDF][PDF] Stromal cells covering omental fat-associated lymphoid clusters trigger formation of neutrophil aggregates to capture peritoneal contaminants

LH Jackson-Jones, P Smith, JR Portman… - Immunity, 2020 - cell.com
The omentum is a visceral adipose tissue rich in fat-associated lymphoid clusters (FALCs)
that collects peritoneal contaminants and provides a first layer of immunological defense …

[HTML][HTML] Milky spots promote ovarian cancer metastatic colonization of peritoneal adipose in experimental models

R Clark, V Krishnan, M Schoof, I Rodriguez… - The American journal of …, 2013 - Elsevier
The goal of controlling ovarian cancer metastasis formation has elicited considerable
interest in identifying the tissue microenvironments involved in cancer cell colonization of the …

[PDF][PDF] Omental milky spots develop in the absence of lymphoid tissue-inducer cells and support B and T cell responses to peritoneal antigens

J Rangel-Moreno, JE Moyron-Quiroz, DM Carragher… - Immunity, 2009 - cell.com
The omentum is a site of B1 cell lymphopoiesis and immune responsiveness to T cell-
independent antigens. However, it is unknown whether it supports immune responses …

Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum

WJ Lee, SY Ko, MS Mohamed, HA Kenny… - Journal of Experimental …, 2019 - rupress.org
Ovarian cancer preferentially metastasizes to the omentum, a fatty tissue characterized by
immune structures called milky spots, but the cellular dynamics that direct this tropism are …

The peritoneum: healing, immunity, and diseases

A Capobianco, L Cottone, A Monno… - The Journal of …, 2017 - Wiley Online Library
The peritoneum defines a confined microenvironment, which is stable under normal
conditions, but is exposed to the damaging effect of infections, surgical injuries, and other …

[HTML][HTML] Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer

A Etzerodt, M Moulin, TK Doktor, M Delfini… - Journal of Experimental …, 2020 - rupress.org
Experimental and clinical evidence suggests that tumor-associated macrophages (TAMs)
play important roles in cancer progression. Here, we have characterized the ontogeny and …