The initial contact with blood and its components, including plasma proteins and platelets,
directs the body's response to foreign materials. Natural scaffolds of extracellular matrix or …

Fibrinogen nanofibers hold great potential for wound healing applications since they mimic
the native blood clot architecture and offer important binding sites to support fibroblast …

Although the biology of platelet adhesion on subendothelial matrix after vascular injury is
well characterized, how the matrix biophysical properties affect platelet physiology is …

As platelets aggregate and activate at the site of vascular injury to stem bleeding, they are
subjected to a myriad of biochemical and biophysical signals and cues. As clot formation …

Self-assembled fibrinogen nanofibers are promising candidates for skin tissue engineering
due to their biocompatibility and ability to mimic the native blood clot architecture. Here, we …

The conformational state of adsorbed human plasma fibrinogen (HPF) has been recognized
as the determinant factor in platelet adhesion and thrombus formation on blood-contacting …

Understanding platelet–surface activation is of clinical importance because it directly
involves the formation of a hemostatic plug or blood clot at sites of vascular injury. Although …

Targeted delivery of therapeutic and imaging agents in the vascular compartment represents
a significant hurdle in using nanomedicine for treating hemorrhage, thrombosis, and …

Collagen, a strong platelet activator, is recognized by integrin α2β1 and GPVI. It induces
aggregation, if added to suspended platelets, or platelet adhesion if immobilized to a …

The adhesion of platelets to surfaces crucially governs the blood compatibility of
biomaterials, and thus it decides the successful application of biomaterials to blood …