Heart failure (HF) is a major and growing public health problem. This condition is associated
with poor prognosis, a high rate of mortality, frequent hospitalization and increasing costs to …

Sympathovagal imbalance contributes to progressive worsening of heart failure (HF) and is
associated with untoward clinical outcomes. Based on compelling pre-clinical studies that …

Heart failure (HF) is associated with significant morbidity and mortality. The disease is
characterised by autonomic imbalance with increased sympathetic activity and withdrawal of …

It has been known for many decades that multiple abnormalities of the autonomic nervous
system (ANS) are present in heart failure (HF). Moreover, many of the effective therapies …

Conclusive evidence demonstrates that the sympathetic nervous system activation is a
hallmark of congestive heart failure. This has been shown via a variety of biochemical …

Congestive heart failure (HF), a disease with high mortality and increasing prevalence, 1 is
characterized by autonomic imbalance, including decreased parasympathetic tone, 2, 3 …

Sympathetic activation has been long appreciated exclusively as a fundamental
compensatory mechanism of the failing heart and, thus, welcome and to be supported. In the …

Heart Failure (HF) is associated with sustained acti-vation of the sympathetic nervous
system and withdrawal of parasympathetic tone. Autonomic nervous system modulation has …

Heart failure (HF) continues to impact the population globally with increasing prevalence.
While the pathophysiology of HF is quite complex, the dysregulation of the autonomic …

Aims Patients with sympathetic excess are those most likely to benefit from novel
interventions targeting the autonomic nervous system. To inform such personalized therapy …