The Pulmonary Endothelial Glycocalyx Modifications in Glypican 1 Knockout Mice Do Not Affect Lung Endothelial Function in Physiological Conditions

LNR Thota, JE Lopez Rosales, I Placencia… - International Journal of …, 2023 - mdpi.com
The endothelial glycocalyx is a dynamic signaling surface layer that is involved in the
maintenance of cellular homeostasis. The glycocalyx has a very diverse composition, with …

The endothelial glycocalyx as a double-edged sword in microvascular homeostasis and pathogenesis

N Villalba, S Baby, SY Yuan - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Expressed on the endothelial cell (EC) surface of blood vessels, the glycocalyx (GCX), a
mixture of carbohydrates attached to proteins, regulates the access of cells and molecules in …

Endothelial glycocalyx as a critical signalling platform integrating the extracellular haemodynamic forces and chemical signalling

Y Zeng - Journal of cellular and molecular medicine, 2017 - Wiley Online Library
The glycocalyx covers the human mammalian cells and plays important roles in stroke,
inflammation and atherosclerosis. It has also been shown to be involved in endothelial …

The endothelial glycocalyx: an important regulator of the pulmonary vascular barrier

Y Yang, EP Schmidt - Tissue barriers, 2013 - Taylor & Francis
Once thought to be a structure of small size and uncertain significance, the endothelial
glycocalyx is now known to be an important regulator of endothelial function. Studies of the …

The glycocalyx core protein Glypican 1 protects vessel wall endothelial cells from stiffness-mediated dysfunction and disease

M Mahmoud, M Mayer, LM Cancel… - Cardiovascular …, 2021 - academic.oup.com
Aims Arterial stiffness is an underlying risk factor and a hallmark of cardiovascular diseases.
The endothelial cell (EC) glycocalyx is a glycan rich surface layer that plays a key role in …

Insights into the Molecular Mechanism of Endothelial Glycocalyx Dysfunction during Heart Surgery

A Kršek, L Batičić, B Ćurko-Cofek, T Batinac… - Current Issues in …, 2024 - mdpi.com
The endothelial glycocalyx (EGC) is a layer of proteoglycans (associated with
glycosaminoglycans) and glycoproteins, which adsorbs plasma proteins on the luminal …

The role of endothelial glycocalyx in health and disease

O Yilmaz, B Afsar, A Ortiz, M Kanbay - Clinical kidney journal, 2019 - academic.oup.com
The endothelium is the largest organ in the body and recent studies have shown that the
endothelial glycocalyx (eGCX) plays a major role in health and disease states. The integrity …

The endothelial glycocalyx: its structure and role in eNOS mechano-activation

EE Ebong, DC Spray, JM Tarbell - Proceedings of the 2010 …, 2010 - ieeexplore.ieee.org
The endothelial glycocalyx (GCX) mediates flow-induced nitric oxide release via heparan
sulfate (HS), but the GCX structure is unclear and the specific HS core protein (s) involved in …

Endothelial glycocalyx: Novel insight into atherosclerosis

Y Zeng - Journal of Biomedicine, 2017 - jbiomed.com
The evidence shows that endothelial glycocalyx exerts an important role in inflammation and
atherosclerosis. We previously demonstrated that hydrodynamic force such as shear stress …

The endothelial glycocalyx: a possible therapeutic target in cardiovascular disorders

A Milusev, R Rieben, N Sorvillo - Frontiers in cardiovascular medicine, 2022 - frontiersin.org
The physiological, anti-inflammatory, and anti-coagulant properties of endothelial cells
(ECs) rely on a complex carbohydrate-rich layer covering the luminal surface of ECs, called …