Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear
lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is …

Lamins are nuclear intermediate filaments. In addition to their structural roles, they are
implicated in basic nuclear functions such as chromatin organization, DNA replication …

Hutchinson-Gilford progeria syndrome (HGPS) is a lethal genetic disorder characterized by
premature aging. HGPS is most commonly caused by a de novo single-nucleotide …

Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare premature aging
disease presenting many features resembling the normal aging process. HGPS patients die …

The discoveries of at least eight human diseases arising from mutations in LMNA, which
encodes the nuclear A-type lamins, have revealed the nuclear envelope as an organelle …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to
a severe premature ageing phenotype, caused by mutations in the LMNA gene. The LMNA …

Lamin A is a component of the nuclear envelope that is synthesized as a precursor prelamin
A molecule and then processed into mature lamin A through sequential steps of …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare, debilitating disease with early
mortality and rapid onset of aging-associated pathologies. It is linked to mutations in LMNA …

Hutchinson‐Gilford progeria syndrome (HGPS) is a rare precocious aging syndrome caused
by mutations in LMNA that lead to synthesis of a mutant form of prelamin A, generally called …

Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder that
causes premature, rapid aging shortly after birth. Recently, de novo point mutations in the …