[ES] El accidente cerebrovascular es una patología caracterizada por la restricción de la
disponibilidad de oxígeno y nutrientes debido a un flujo sanguíneo deficiente. Dependiendo …

The regeneration of adult peripheral neurons after transection is slow, incomplete and
encumbered by severe barriers to proper regrowth. The role of RHOA GTPase has not been …

Generally, the axons in the adult mammalian central nervous system (CNS) do not
regenerate after injuries. This lack of regeneration results in partial disability or complete …

In injured adult neurons, the process of axonal regrowth and reestablishment of the
neuronal function have to be activated. We assessed in this study whether RhoA, a key …

Background Blockade of the small GTPase Rho (ras homology protein) or of its downstream
target Rho-associated kinase has been shown to promote axon regeneration in vitro and in …

Axonal regeneration in the central nervous system is blocked by many different growth
inhibitory factors. Some of these inhibitors act on neurons by activating RhoA and Rho …

Publisher Summary This chapter discusses the inactivation of intracellular Rho to stimulate
axon growth and regeneration. In tissue culture, inactivation of the Rho signaling pathway is …

Abstract The small GTPase RhoA and its down-stream effector Rho-kinase (ROCK) are
important effector molecules of the neuronal cytoskeleton. Modulation of the RhoA/ROCK …

Abstract The Rho/Rho-kinase signaling pathway plays an important role in cerebral
ischemia/reperfusion injury. However, very few studies have examined in detail the changes …

Rho kinase inhibitor fasudil hydrochloride has been shown to reduce cerebral vasospasm,
to inhibit inflammation and apoptosis and to promote the recovery of neurological function …