Cancer is the leading cause of mortality all over the world. Scientific investigation has
demonstrated that disruptions in the process of autophagy are frequently interrelated with …

The marine environment produces natural products from a variety of structural classes
exhibiting activity against numerous disease targets. Historically marine natural products …

Novel secondary metabolites from marine macroorganisms and marine-derived
microorganisms have been intensively investigated in the last few decades. Several classes …

Naturally occurring indole alkaloids are ubiquitously present in nature and possess
extensive biological properties and structural diversity. Mechanistically, naturally occurring …

Marine indole alkaloids comprise a large and steadily growing group of secondary
metabolites. Their diverse biological activities make many compounds of this class attractive …

Cancer is a leading cause of death worldwide, and cancer development is often associated
with disturbances in the autophagy process. Autophagy is a catabolic process involved in …

Indole is a versatile pharmacophore widely distributed in bioactive natural products. This
privileged scaffold has been found in a variety of molecules isolated from marine organisms …

Cancer is the leading cause of death globally, with an increasing number of cases being
annually reported. Nature-derived metabolites have been widely studied for their potential …

Indole alkaloids are heterocyclic natural products with extensive pharmacological activities.
As an important source of lead compounds, many clinical drugs have been derived from …

The present review describes research on novel natural antitumor alkaloids isolated from
marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 …